Expression of β-catenin and AXIN2 in ameloblastomas

Zhenhui Wei; Ming Zhong; Yan Guo; Yan Wang; Meisi Ren; Zhaoyuan Wang

doi:10.5114/wo.2013.35278

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2013
vol. 17

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abstract:

Original paper

Expression of β-catenin and AXIN2 in ameloblastomas

Zhenhui Wei

,

Ming Zhong

,

Yan Guo

,

Yan Wang

,

Meisi Ren

,

Zhaoyuan Wang

Wspolczesna Onkol 2013; 17 (3): 250–256

DOI: https://doi.org/10.5114/wo.2013.35278

Online publish date: 2013/06/28

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Aim of the study: To investigate the expression status and association of β-catenin and AXIN2 in ameloblastoma.

Material and methods: 30 ameloblastoma specimens and 10 normal oral mucosa tissues were enrolled in the study. The protein and RNA levels of

β-catenin and AXIN2 were detected by immunohistochemistry staining, Western blot, and real-time PCR analysis. The relationship between β-catenin and AXIN2 protein and clinico-pathological parameters and prognosis was subsequently determined.

Results: The results show that β-catenin mRNA expression was 1.24-fold higher in ameloblastomas than that in normal mucosa tissues, but AXIN2 mRNA expression was 0.47-fold lower in ameloblastomas than that in normal mucosa tissues (p < 0.05). The Western blot results show that β-catenin and AXIN2 protein in ameloblastomas had a significantly higher level than normal mucosa tissues

(p < 0.05). Immunohistochemical staining of β-catenin and AXIN2 protein in ameloblastoma was expressed at a higher level than normal oral mucosa (p < 0.05).

Conclusions: AXIN2 and β-catenin play an important role in the tumorigenesis and progression of ameloblastoma.

keywords:

Expression of β-catenin and AXIN2 in ameloblastomas

Zhenhui Wei , Ming Zhong , Yan Guo , Yan Wang , Meisi Ren , Zhaoyuan Wang

ameloblastoma, β-catenin, AXIN2, Wnt pathway

Zhenhui Wei

,

Ming Zhong

,

Yan Guo

,

Yan Wang

,

Meisi Ren

,

Zhaoyuan Wang