eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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3/2009
vol. 8
 
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abstract:
Original paper

Expression of lymphangiogenesis marker Prox-1 in ovarian cancer

Magdalena Mazurek
,
Wiesława Bednarek
,
Robert Jach
,
Józef Kotarski

Przegląd Menopauzalny 2009; 3: 121–126
Online publish date: 2009/07/02
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Lymphangiogenesis in ovarian cancer is not yet well characterised. Lymphatic vessels help tumor progression, and simultaneously represent the most important pathway for neoplastic cell dissemination. The estimation of the lymphatic endothelium markers expression can be useful in the evaluation of lymphangiogenesis, cancer progression and ability of metastatic spreading. It is especially interesting the research on specific lymphatic markers, such as Prox-1, nuclear transcription factor. We investigated correlation between expression of Prox-1, histological type and grading of ovarian cancer. Our studies show the expression of Prox-1 in all investigated histological types of ovarian cancer. We did not observe the statistis correlation (p > 0.05) with reference to type and grading. Further investigations taking into account bigger number of patients, spectrum of operation, and other exponents of limphangiogenesis, probably allow to discover different correlations.
keywords:

ovarian cancer, lymphangiogenesis, transcription factor Prox-1
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