Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia

Edyta Wlaźlak; Grzegorz Surkont; Józef Kobos; Wiesław Tyliński; Tomasz Stetkiewicz; Jacek Suzin

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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6/2006
vol. 5

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abstract:

Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia

Edyta Wlaźlak

,

Grzegorz Surkont

,

Józef Kobos

,

Wiesław Tyliński

,

Tomasz Stetkiewicz

,

Jacek Suzin

Przegląd Menopauzalny 2006; 6: 363–366

Online publish date: 2007/02/08

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AMA

Wlaźlak E, Surkont G, Kobos J, Tyliński W, Stetkiewicz T, Suzin J. Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia. Menopause Review/Przegląd Menopauzalny. 2006;5(6):363-366.

APA

Wlaźlak, E., Surkont, G., Kobos, J., Tyliński, W., Stetkiewicz, T.,  & Suzin, J. (2006). Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia. Menopause Review/Przegląd Menopauzalny, 5(6), 363-366.

Chicago

Wlaźlak, Edyta, Grzegorz Surkont, Józef Kobos, Wiesław Tyliński, Tomasz Stetkiewicz,  and Jacek Suzin. 2006. "Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia". Menopause Review/Przegląd Menopauzalny 5 (6): 363-366.

Harvard

Wlaźlak, E., Surkont, G., Kobos, J., Tyliński, W., Stetkiewicz, T.,  and Suzin, J. (2006). Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia. Menopause Review/Przegląd Menopauzalny, 5(6), pp.363-366.

MLA

Wlaźlak, Edyta et al. "Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia." Menopause Review/Przegląd Menopauzalny, vol. 5, no. 6, 2006, pp. 363-366.

Vancouver

Wlaźlak E, Surkont G, Kobos J, Tyliński W, Stetkiewicz T, Suzin J. Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia. Menopause Review/Przegląd Menopauzalny. 2006;5(6):363-366.

Excessive extracellular proteolysis attributable to abnormally high matrix metalloproteinases (MMPs) activities, is observed in many invasive neoplasms.
Objective: The aim of our study was to compare the expression of matrix metalloproteinases MMP-1, MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 in the glandular compartment of endometrial cancer cells and in hyperplastic endometrial cells without atypia.
Material and methods: Out of the total of 500 specimens from the uterine cavity, obtained from women who have undergone D&C in the First Institute of Obstetrics and Gynecology Medical University of Lodz, we have selected twenty four: twelve cases of endometrial carcinoma and twelve – of hyperplasia without atypia.
Results: MMP-1, MMP-9 oraz TIMP-1 expression was higher in endometrial carcinoma group in comparison to endometrial hyperplasia group. The differences were statistically significant. In most of the cases of endometrial carcinoma TIMP-1 activity was small.
Discussion: Our results suggest that interaction between MMPs and TIMPs may play important role in invasive processes of endometrial carcinoma. Key words: endometrium, endometrial cancer, hyperplastic endometrium, matrix metalloproteinases, MMPs, tissue inhibitors of metalloproteinases, TIMPs

keywords:

Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia

Edyta Wlaźlak , Grzegorz Surkont , Józef Kobos , Wiesław Tyliński , Tomasz Stetkiewicz , Jacek Suzin

endometrium, endometrial cancer, hyperplastic endometrium, matrix metalloproteinases, MMPs, tissue inhibitors of metalloproteinases, TIMPs

Edyta Wlaźlak

,

Grzegorz Surkont

,

Józef Kobos

,

Wiesław Tyliński

,

Tomasz Stetkiewicz

,

Jacek Suzin