eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
1/2012
vol. 63
 
Share:
Send email
Share:
abstract:

Expression of selected neuropeptides in pathogenesis of bullous pemphigoid and dermatitis herpetiformis

Anna Cynkier
,
Agnieszka Żebrowska
,
Małgorzata Wągrowska-Danilewicz
,
Marian Danilewicz
,
Anna Erkiert-Polguj
,
Olga Stasikowska-Kanicka
,
Anna Sysa-Jędrzejowska
,
Elżbieta Waszczykowska

Pol J Pathol 2012; 1: 31-39
Online publish date: 2012/04/24
View full text Get citation
 
Bullous pemphigoid (BP) and dermatitis herpetiformis (DH) are chronic subepidermal bullous diseases, which progress together with an itch and an inflammatory reaction. These symptoms may be the cause of a phenomenon described in the literature as a neurogenic skin inflammation. Neuropeptides are one of the mediators which take part in this process. The aim of our study was to indicate the expression of selected neuropeptides – CRF (corticotropin releasing factor), CGRP (calcitonin gene-related peptide), NKB (neurokinin B), SP (substance P) and the receptor for endothelin B (ETRB) – in the skin of patients suffering from BP or DH. A significantly increased expression of CRF was found in the specimen collected from the skin lesions of patients with BP and DH as well as a significantly increased expression of receptor for endothelin B in the patients with DH by the immunohistochemical method. The results obtained give evidence of a possible participation of CRF and receptor for endothelin B in the pathogenesis of the itch in the dermatitis herpetiformis as well as CRF in bullous pemphigoid.
keywords:

bullous pemphigoid (BP), dermatitis herpetiformis (DH), neuropeptides
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.