Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment

Akshay Anand; Suyash Singh; Abhinav A. Sonkar; Nuzhat Husain; Kul Ranjan Singh; Sudhir Singh; Jitendra K. Kushwaha

doi:10.5114/wo.2017.68623

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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2/2017
vol. 21

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abstract:

Original paper

Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment

Akshay Anand

,

Suyash Singh

,

Abhinav A. Sonkar

,

Nuzhat Husain

,

Kul Ranjan Singh

,

Sudhir Singh

,

Jitendra K. Kushwaha

Contemp Oncol (Pozn) 2017; 21 (3): 145–151

DOI: https://doi.org/10.5114/wo.2017.68623

Online publish date: 2017/06/30

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AMA

Anand A, Singh S, Sonkar A, et al. Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment. Contemporary Oncology/Współczesna Onkologia. 2017;21(2):145-151. doi:10.5114/wo.2017.68623.

APA

Anand, A., Singh, S., Sonkar, A., Husain, N., Singh, K.,  & Singh, S. et al. (2017). Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment. Contemporary Oncology/Współczesna Onkologia, 21(2), 145-151. https://doi.org/10.5114/wo.2017.68623

Chicago

Anand, Akshay, Suyash Singh, Abhinav A. Sonkar, Nuzhat Husain, Kul Ranjan Singh, Sudhir Singh,  and Jitendra K. Kushwaha. 2017. "Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment". Contemporary Oncology/Współczesna Onkologia 21 (2): 145-151. doi:10.5114/wo.2017.68623.

Harvard

Anand, A., Singh, S., Sonkar, A., Husain, N., Singh, K., Singh, S.,  and Kushwaha, J. (2017). Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment. Contemporary Oncology/Współczesna Onkologia, 21(2), pp.145-151. https://doi.org/10.5114/wo.2017.68623

MLA

Anand, Akshay et al. "Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment." Contemporary Oncology/Współczesna Onkologia, vol. 21, no. 2, 2017, pp. 145-151. doi:10.5114/wo.2017.68623.

Vancouver

Anand A, Singh S, Sonkar A, Husain N, Singh K, Singh S et al. Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment. Contemporary Oncology/Współczesna Onkologia. 2017;21(2):145-151. doi:10.5114/wo.2017.68623.

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Aim of the study: Vitamin D receptor (VDR) expression and serum vitamin D scores in oral premalignant lesions and oral cancer have not been widely analyzed. The role of vitamin D supplementation in advanced oral cancer for improving quality of life (QOL) is also a matter of research.

Material and methods: Vitamin D receptor expression and vitamin D scores were analyzed in normal oral mucosa (n = 95), leukoplakia (n = 23) and oral cancer (n = 87). 45 patients with advanced oral cancer subjected to chemoradiation were evaluated for the effect of vitamin D supplementation on most observable QOL parameters such as oral mucositis, swallowing performance and overall QOL.

Results: Vitamin D receptor expression was increased in oral neoplastic lesions. Vitamin D scores were significantly lower in cases compared to healthy controls (p = 0.002). Vitamin D supplementation significantly reduced the therapy-related toxicities in advanced cancer, thus reducing morbidity and improving QOL.

Conclusions: Vitamin D receptor expression is increased in premalignant lesions and oral cancer. Vitamin D insufficiency and deficiency are prevalent in patients with oral neoplastic lesions. Vitamin D supplementation has a role in reducing treatment-related toxicities, especially in advanced cancer.

keywords:

Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment

Akshay Anand , Suyash Singh , Abhinav A. Sonkar , Nuzhat Husain , Kul Ranjan Singh , Sudhir Singh , Jitendra K. Kushwaha

calcitriol receptor, calcidiol levels, oral neoplasms, quality of life

Akshay Anand

,

Suyash Singh

,

Abhinav A. Sonkar

,

Nuzhat Husain

,

Kul Ranjan Singh

,

Sudhir Singh

,

Jitendra K. Kushwaha