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ISSN: 1233-9687
Polish Journal of Pathology
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2/2016
vol. 67
 
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abstract:
Original paper

Expression pattern of ISL-1, TTF-1 and PAX5 in olfactory neuroblastoma

Piotr Czapiewski
,
Adam Gorczyński
,
Johannes Haybaeck
,
Krzysztof Okoń
,
Joanna Reszeć
,
Wojciech Skrzypczak
,
Jarosław Dzierżanowski
,
Michał Kunc
,
Joanna Karczewska
,
Wojciech Biernat

Pol J Pathol 2016; 67 (2): 130-135
DOI: https://doi.org/10.5114/pjp.2016.61448
Online publish date: 2016/08/02
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Olfactory neuroblastoma (ONB) is a rare neoplasm of the sinonasal area with neuroendocrine differentiation. ISL-1, TTF-1 and PAX5 are transcription factors that are frequently upregulated in tumors showing neuroendocrine differentiation. The aim of our study was to evaluate these markers in a group of ONBs.

We included 11 ONBs from 4 large university hospitals. Immunohistochemical expression of TTF-1, PAX5 and ISL-1 was evaluated.

TTF-1, ISL-1 and PAX5 were expressed in 3/11 cases (27.27%, h-score: 3-45), 7/11 cases (63.64%, h-score: 23-200), and in 3/11 cases (27.77%, h-score 3-85), respectively. The patient with the strongest PAX5 reactivity exhibited an aggressive clinical course with rapid dissemination to the spine and death shortly after the diagnosis.

No significant correlation in the expression of PAX5 and TTF-1 ( = 0.43; p = 0.18) was observed.

ISL-1 is widely expressed in tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis. TTF-1 positivity does not exclude the diagnosis of primary ONB, although usually only a small percentage of cells are positive.

PAX5 expression is infrequent (27.27%) in ONB; however, if present it can be associated with a very aggressive clinical course.
keywords:

olfactory neuroblastoma, esthesioneuroblastoma, ISL-1, TTF-1, PAX5
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