FIB-5 versus FIB-4 index for assessment of hepatic fibrosis in chronic hepatitis B affected patients

Khaled Metwally; Maha Elsabaawy; Mohamed Abdel-Samiee; Wessam Morad; Nermine Ehsan; Eman Abdelsameea

doi:10.5114/ceh.2020.102157

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

FIB-5 versus FIB-4 index for assessment of hepatic fibrosis in chronic hepatitis B affected patients

Khaled Metwally

¹

,

Maha Elsabaawy

¹

,

Mohamed Abdel-Samiee

¹

,

Wessam Morad

²

,

Nermine Ehsan

³

,

Eman Abdelsameea

¹

Hepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Egypt
Community and Preventive Medicine Department, National Liver Institute, Menoufia University, Egypt
Pathology Department, National Liver Institute, Menoufia University, Egypt

Clin Exp HEPATOL 2020; 6, 4: 335–338

DOI: https://doi.org/10.5114/ceh.2020.102157

Online publish date: 2020/12/30

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Aim of the study
Chronic hepatitis B virus (HBV) infection is one of the major health problems worldwide. Use of non-invasive tests for assessment of hepatic ﬁbrosis such as the FIB-4 index could be used to avoid liver biopsy. Another promising noninvasive test, FIB-5, could also be used to detect signiﬁcant hepatic ﬁbrosis. The aim of the study was to compare the use of FIB-5 and FIB-4 as noninvasive markers to assess chronic HBV-related hepatic ﬁbrosis.

Material and methods
This study was done on 176 chronic HBV patients who underwent liver biopsy. Grading and staging of liver fibrosis was done according to the METAVIR scoring system. FIB-5 and FIB-4 scores were calculated for all patients.

Results
As regards FIB-4 for differentiation between non-signiﬁcant ﬁbrosis (group I) and signiﬁcant ﬁbrosis (group II), at a cutoff level of 1.28 with positive predictive value (PPV) 41.4% and speciﬁcity 48% while at a cutoff level of 7.08 with PPV 98.8% and specificity 98% for FIB-5.

Conclusions
As regards both scores, the FIB-5 score was more specific than FIB-4 for diagnosing signiﬁcant from nonsignificant hepatic fibrosis in patients with chronic HBV infection.

keywords:

FIB-5 versus FIB-4 index for assessment of hepatic fibrosis in chronic hepatitis B affected patients

Khaled Metwally 1 , Maha Elsabaawy 1 , Mohamed Abdel-Samiee 1 , Wessam Morad 2 , Nermine Ehsan 3 , Eman Abdelsameea 1

FIB-5, FIB-4, ﬁbrosis, biopsy, chronic HBV

Khaled Metwally

¹

,

Maha Elsabaawy

¹

,

Mohamed Abdel-Samiee

¹

,

Wessam Morad

²

,

Nermine Ehsan

³

,

Eman Abdelsameea

¹