1. Piel FB, Weatherall DJ. The α-thalassemias. N Engl J Med 2014; 371(20): 1908–1916.
2.
Cousens NE, Gaff CL, Metcalfe SA, et al. Carrier screening for beta-thalassaemia: a review of international practice. Eur J Hum Genet 2010; 18(10): 1077–1083.
3.
Shakeel M, Arif M, Rehman SU, et al. Investigation of molecular heterogeneity of β-thalassemia disorder in District Charsadda of Pakistan. Pak J Med Sci 2016; 32(2): 491–494.
4.
Maheen H, Malik F, Siddique B, et al. Assessing Parental Knowledge About Thalassemia in a Thalassemia Center of Karachi, Pakistan. J Genet Couns 2015; 24(6): 945–951.
5.
Thavorncharoensap M, Torcharus K, Nuchprayoon I, et al. Factors affecting health-related quality of life in Thai children with thalassemia. BMC Blood Disord 2010; 10: 1, doi: 10.1186/1471-2326-10-1.
6.
Caro JJ, Ward A, Green TC, et al. Impact of thalassemia major on patients and their families. Acta Haematol 2002; 107(3): 150–157.
7.
Toumba M, Sergis A, Kanaris C, et al. Endocrine complications in patients with Thalassaemia Major. Pediatr Endocrinol Rev 2007; 5(2): 642–648.
8.
Chern JP, Su S, Lin KH, et al. Survival, mortality, and complications in patients with β‐Thalassemia major in northern Taiwan. Pediatr Blood Cancer 2007; 48(5): 550–554.
9.
Al-Elq AH, Al-Saeed HH. Endocrinopathies in patients with thalassemias. Saudi Med J 2004; 25(10): 1347–1351.
10.
De Sanctis V, Roos M, Gasser T, et al. Impact of long-term iron chelation therapy on growth and endocrine functions in thalassaemia. J Pediatr Endocrinol Metab 2006; 19(4): 471–480.
11.
Shamshirsaz AA, Bekheirnia MR, Kamgar M, et al. Metabolic and endocrinologic complications in beta-thalassemia major: a multicenter study in Tehran. BMC Endocr Disord 2003; 3(1): 4.
12.
Malik S, Syed S, Ahmed N. Complications in transfusion-dependent patients of ß-thalassemia major. Pak J Med Sci 2009; 25(4): 678–682.
13.
Prati D, Maggioni M, Milani S, et al. Clinical and histological characterization of liver disease in patients with transfusion-dependent beta-thalassemia. A multicenter study of 117 cases. Haematologica 2004; 89(10): 1179–1186.
14.
Mazzone L, Battaglia L, Andreozzi F, et al. Emotional impact in β-thalassaemia major children following cognitive-behavioural family therapy and quality of life of caregiving mothers. Clin Pract Epidemiol Ment Health 2009; 5: 5, doi: 10.1186/1745-0179-5-5.
15.
Gharaibeh H, Gharaibeh M. Factors influencing health‐related quality of life of thalassaemic Jordanian children. Child Care Health Dev 2012; 38(2): 211–218.
16.
Mikelli A, Tsiantis J. Brief report: depressive symptoms and quality of life in adolescents with b-thalassaemia. J Adolesc 2004; 27(2): 213–216.
17.
Ismail A, Campbell MJ, Ibrahim HM, et al. Health related quality of life in Malaysian children with thalassaemia. Health Qual Life Outcomes 2006; 4: 39.
18.
Pakbaz Z, Treadwell M, Yamashita R, et al. Quality of life in patients with thalassemia intermedia compared to thalassemia major. Ann N Y Acad Sci 2005; 1054: 457–461.
19.
Abetz L, Baladi J-F, Jones P, et al. The impact of iron overload and its treatment on quality of life: results from a literature review. Health Qual Life Outcomes 2006; 4: 73.
20.
Shaligram D, Girimaji S, Chaturvedi S. Psychological problems and quality of life in children with thalassemia. Indian J Pediatr 2007; 74(8): 727–730.
21.
Telfer P, Constantinidou G, Andreou P, et al. Quality of life in thalassemia. Ann N Y Acad Sci 2005; 1054: 273–282.
22.
Ammad SA, Mubeen SM, Shah SFUH, et al. Parents’ opinion of quality of life (QoL) in Pakistani thalassaemic children. J Pak Med Assoc 2011; 61(5): 470–473.
23.
Kotrlik J, Higgins C. Organizational research: determining appropriate sample size in survey research appropriate sample size in survey research. Information Technology, Learning, and Performance Journal 2001; 19(1): 43.
24.
Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med 1993; 118(8): 622–629.
25.
Pal DK. Quality of life assessment in children: a review of conceptual and methodological issues in multidimensional health status measures. J Epidemiol Community Health 1996; 50(4): 391–396.
26.
Varni JW, Seid M, Rode CA. The PedsQL™: measurement model for the pediatric quality of life inventory. Med Care 1999; 37(2): 126–139.
27.
Varni JW, Seid M, Kurtin PS. Pediatric health-related quality of life measurement technology: a guide for health care decision makers. J Clin Outcomes Manag 1999; 6: 33–44.
28.
Netuveli G, Blane D. Quality of life in older ages. Br Med Bull 2008; 85: 113–126.
29.
Dolai TK, Dutta S, Bhattacharyya M, et al. Prevalence of hemoglobinopathies in rural Bengal, India. Hemoglobin 2012; 36(1): 57–63.
30.
Borgna-Pignatti C, Rugolotto S, De Stefano P, et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica 2004; 89(10): 1187–1193.
31.
Nielsen P, Günther U, Dürken M, et al. Serum ferritin iron in iron overload and liver damage: correlation to body iron stores and diagnostic relevance. J Lab Clin Med 2000; 135(5): 413–418.
32.
Oktenli C, Bulucu F. Renal tubular dysfunction in a patient with beta-thalassemia minor. Nephron 2002; 92(1): 222–223.
33.
Rasool M, Malik A, Jabbar U, et al. Effect of iron overload on renal functions and oxidative stress in beta thalassemia patients. Saudi Med J 2016; 37(11): 1239–1242.
34.
Arosio P, Levi S. Ferritin, iron homeostasis, and oxidative damage 1, 2. Free Radic Biol Med 2002; 33(4): 457–463.
