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4/2024
vol. 75
 
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Original paper

Fat mass and obesity-associated protein expression in colorectal cancer and its influence on the biological behaviour of colorectal cancer cells

Huihui Wu
1
,
Yibo Wu
1
,
Zhishan Zhang
1
,
Qinglin Chen
1
,
Tingjin Zheng
1
,
Hui Zhong
2

  1. Department of Clinincal Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian, China
  2. Clinical Laboratory, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China
Pol J Pathol 2024; 75 (4): 343-352
DOI: https://doi.org/10.5114/pjp.2024.146501
Online publish date: 2024/12/30
Article file
- Fat mass and obesity-associated.pdf  [0.47 MB]
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1. Jia G, Fu Y, Zhao X, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 2011; 7: 885-887.
2. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71: 209-249.
3. Tan Z, Shi S, Xu J, et al. RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m(6)A-YTHDF2-dependent manner. Oncogene 2022; 41: 2860-2872.
4. Wang D, Qu X, Lu W, et al. N(6)-methyladenosine RNA demethylase FTO promotes gastric cancer metastasis by down-regulating the m6A methylation of ITGB1. Front Oncol 2021; 11: 681280. DOI: 10.3389/fonc.2021.681280.
5. Zhou Y, Wang Q, Deng H, et al. N6-methyladenosine demethylase FTO promotes growth and metastasis of gastric cancer via m(6)A modification of caveolin-1 and metabolic regulation of mitochondrial dynamics. Cell Death Dis 2022; 13: 72. DOI: 10.1038/s41419-022-04503-7.
6. Liu S, Huang M, Chen Z, et al. FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13. Exp Cell Res 2020; 389: 111894. DOI: 10.1016/j.yexcr.2020.111894.
7. Li J, Han Y, Zhang H, et al. The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA. Biochem Biophys Res Commun 2019; 512: 479-485.
8. Zhang L, Wan Y, Zhang Z, et al. FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway. RNA Biol 2021; 18: 1265-1278.
9. Yang S, Wei J, Cui YH, et al. m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun 2019; 10: 2782. DOI: 10.1038/s41467-019-10669-0
10. Huang H, Wang Y, Kandpal M, et al. FTO-dependent N (6)-me­thyladenosine modifications inhibit ovarian cancer stem cell self-renewal by blocking cAMP signaling. Cancer Res 2020; 80: 3200-3214.
11. Huang J, Sun W, Wang Z, et al. FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner. J Exp Clin Cancer Res 2022; 41: 42. DOI: 10.1186/s13046-022-02254-z.
12. Yue C, Chen J, Li Z, et al. microRNA-96 promotes occurrence and progression of colorectal cancer via regulation of the AMPK-2-FTO-m6A/MYC axis. J Exp Clin Cancer Res 2020; 39: 240. DOI: 10.1186/s13046-020-01731-7.
13. Zou D, Dong L, Li C, et al. The m(6)A eraser FTO facilitates proliferation and migration of human cervical cancer cells. Cancer Cell Int 2019; 19: 321. DOI: 10.1186/s12935-019-1045-1.
14. Wang F, Hu Y, Wang H, et al. LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2. J Exp Clin Cancer Res 2023; 42: 267. DOI: 10.1186/s13046-023-02847-2.
15. Ruan DY, Li T, Wang YN, et al. FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis. Oncogene 2021; 40: 5168-5181.
Copyright: © 2024 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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