Fatal outcome of a hypersensitivity reaction to paclitaxel: a case report

Jan P. van Meerbeeck; Jeroen S. Kloover; Michael A. den Bakker

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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8/2002
vol. 6

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abstract:

Fatal outcome of a hypersensitivity reaction to paclitaxel: a case report

Jan P. van Meerbeeck

,

Jeroen S. Kloover

,

Michael A. den Bakker

Współ Onkol (2002), vol. 6, 8, 486-489

Online publish date: 2003/04/11

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Hypersensitivity reactions (HSRs) to paclitaxel are frequently encountered in patients receiving this anti-tumor drug. Oral pre-medication with dexamethasone at a dose of 20 mg and given orally at 12 and 6 hours before infusion of paclitaxel have been shown to reduce the incidence of paclitaxel-induced HSRs significantly. However, due to logistic factors, short-course pre-medication with intravenously administered dexamethasone given 30 minutes prior to paclitaxel infusion became customary and retrospective analysis showed that this pre-medication schedule was as effective as the oral regimen. In this case report we describe the fatal outcome of a HSR in a patient receiving paclitaxel despite short-course pre-medication. The level of evidence supporting the short-course iv pre-medication schedule is challenged, as it is not compatible with the pharmacokinetic properties of dexamethasone.

keywords:

Fatal outcome of a hypersensitivity reaction to paclitaxel: a case report

Jan P. van Meerbeeck , Jeroen S. Kloover , Michael A. den Bakker

hypersensitivity reaction, paclitaxel, anaphylaxis, dexamethasone, premedication, chemotherapy

Jan P. van Meerbeeck

,

Jeroen S. Kloover

,

Michael A. den Bakker