Feeding mice with <i>Aloe vera</i> gel diminishes L-1 sarcoma-induced early neovascular response and tumor growth

Janusz Kocik; Barbara Joanna Bałan; Robert Zdanowski; Leszek Jung; Ewa Skopińska-Różewska; Piotr Skopiński

doi:10.5114/ceji.2014.42116

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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abstract:

**Feeding mice with Aloe vera gel diminishes L-1 sarcoma-induced early neovascular response and tumor growth**

Janusz Kocik

,

Barbara Joanna Bałan

,

Robert Zdanowski

,

Leszek Jung

,

Ewa Skopińska-Różewska

,

Piotr Skopiński

(Centr Eur J Immunol 2014; 39 (1): 14-18

DOI: https://doi.org/10.5114/ceji.2014.42116

Online publish date: 2014/04/17

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Aloe vera (Aloe arborescens, aloe barbadensis) is a medicinal plant belonging to the Liliaceae family. Aloe vera gel prepared from the inner part of Aloe leaves is increasingly consumed as a beverage dietary supplement. Some data suggest its tumor growth modulatory properties. The aim of the present study was to evaluate in Balb/c mice the in vivo influence of orally administered Aloe vera drinking gel on the syngeneic L-1 sarcoma tumor growth and its vascularization: early cutaneous neovascular response, tumor-induced angiogenesis (TIA test read after 3 days), and tumor hemoglobin content measured 14 days after L-1 sarcoma cell grafting.

Feeding mice for 3 days after tumor cell grafting with 150 µl daily dose of Aloe vera gel significantly diminished the number of newly-formed blood vessels in comparison to the controls. The difference between the groups of control and Aloe-fed mice (150 µl daily dose for 14 days) with respect to the 14 days’ tumor volume was on the border of statistical significance. No difference was observed in tumor hemoglobin content.

keywords:

Feeding mice with Aloe vera gel diminishes L-1 sarcoma-induced early neovascular response and tumor growth

Janusz Kocik , Barbara Joanna Bałan , Robert Zdanowski , Leszek Jung , Ewa Skopińska-Różewska , Piotr Skopiński

Aloe vera gel, mice, tumor growth, angiogenesis

**Feeding mice with Aloe vera gel diminishes L-1 sarcoma-induced early neovascular response and tumor growth**

Janusz Kocik

,

Barbara Joanna Bałan

,

Robert Zdanowski

,

Leszek Jung

,

Ewa Skopińska-Różewska

,

Piotr Skopiński