Fibroma of the breast: a rare tumour in the spectrum of the benign spindle cell tumours of the mammary stroma

Magro Gaetano; Angelico Giuseppe; Spadola Saveria; Ragusa Rosalia; Righi Alberto; Orvieto Enrico

doi:10.5114/pjp.2018.76703

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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2/2018
vol. 69

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abstract:

Case report

Fibroma of the breast: a rare tumour in the spectrum of the benign spindle cell tumours of the mammary stroma

Magro Gaetano

,

Angelico Giuseppe

,

Spadola Saveria

,

Ragusa Rosalia

,

Righi Alberto

,

Orvieto Enrico

Pol J Pathol 2018; 69 (2): 189-194

DOI: https://doi.org/10.5114/pjp.2018.76703

Online publish date: 2018/07/06

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Benign spindle cell tumours of the mammary stroma comprises different lesions that show a variable degree of fibroblastic/myofibroblastic differentiation. We herein report a previously under-recognised hypocellular fibrocollagenous tumour of the breast, for which the term “fibroma” is proposed. The tumour was composed of CD34-positive bland-looking spindle cells embedded in an abundant hyalinised stroma. Fluorescence in situ hybridisation (FISH) showed 13q14 deletion in most neoplastic cells, a chromosomal alteration typically found in mammary myofibroblastoma. Based on morphological, immunohistochemical, and cytogenetic features, we suggest that fibroma belongs to the group of the benign spindle cell tumours of the mammary stroma.

keywords:

Fibroma of the breast: a rare tumour in the spectrum of the benign spindle cell tumours of the mammary stroma

Magro Gaetano , Angelico Giuseppe , Spadola Saveria , Ragusa Rosalia , Righi Alberto , Orvieto Enrico

breast, mammary stroma, fibroma, benign spindle cell tumour, 13q14 deletion

Magro Gaetano

,

Angelico Giuseppe

,

Spadola Saveria

,

Ragusa Rosalia

,

Righi Alberto

,

Orvieto Enrico