eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2006
vol. 3
 
Share:
Share:
abstract:

Forum ekspertów
Nitric oxide and peroxynitrite balance in the cardiovascular system: a nanomedical approach

Tadeusz Maliński

Kardiochirurgia i Torakochirurgia Polska 2006; 3 (4): 350–355
Online publish date: 2007/01/10
View full text Get citation
 
A small deviation from the physiological NO concentration may have a significant effect on the function of the cardiovascular system. A deficiency in NO production and concomitant increase in cytotoxic peroxynitrite (ONOO-) has been associated with dysfunctional endothelium. Low level of bioavailable NO and high level of ONOO- are features of several vascular diseases including hypertension, arteriosclerosis, stroke and myocardial infarction. This study used a nanotechnological and nanomedical approach (nanosensors) to measure the release of NO and ONOO- from a single dysfunctional endothelial cell (HUVECs, aortic, cardiac, and endothelial cells). A balance of K=[NO]/[ONOO-] was used as a criterion of endothelial function or dysfunction. Normal HUVECs produced high NO (480+35 nmol/L), low ONOO- (70+4 nmol/L) and a [NO]/[ONOO-] balance was at the level of K=3.5. In the presence of ox-LDL, this balance decreased to K=0.32+0.02. A significant decrease in [NO]/[ONOO-] was observed in hypertensive (SHR) rats (K=1.5+0.1) as compared to normotensive (WKY) rats (K=2.8+0.3). The K balance can be positively shifted by L-arginine or superoxide dismutase. In the failing heart of SHR, K value decreased to 0.38+0.04 from 2.2+0.2 for sham-operated rats. Treatment for 4 weeks with simvastatin (2.5 mg/kg/day) partially but significantly restored the
[NO]/[ONOO-] balance in SHR with a failing heart. Therefore, simvastatin-induced shift of [NO]/[ONOO-] balance may contribute to the clinical usefulness of simvastatin in the treatment of the failing heart.
keywords:

dysfunctional endothelium, nitric oxide, peroxynitrite, statins, heart, vasculature

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.