Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis

Juliana Piedade; Livia Guimarães; Joana Duarte; Lorena Gouveia; Tamar Garfinkel; Zulane Veiga; Camila Alcântara; Hugo Perazzo; Flavia Fernandes; Gustavo Pereira

doi:10.5114/ceh.2022.120030

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis

Juliana Piedade

¹

,

Livia Guimarães

¹

,

Joana Duarte

¹

,

Lorena Gouveia

²

,

Tamar Garfinkel

²

,

Zulane Veiga

¹

,

Camila Alcântara

¹

,

Hugo Perazzo

³

,

Flavia Fernandes

¹

,

Gustavo Pereira

^{1, 2}

Gastroenterology and Hepatology Unit, Bonsucesso Federal Hospital, Ministry of Health, Rio de Janeiro, Brazil
Estácio de Sá University, School of Medicine-IDOMED, Instituto de Educação Médica, Rio de Janeiro, Brazil
Evandro Chagas National Institute of Infectious Disease (INI), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil

Clin Exp HEPATOL 2022; 8, 4: 284-292

DOI: https://doi.org/10.5114/ceh.2022.120030

Online publish date: 2022/11/19

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AMA

Piedade J, Guimarães L, Duarte J, et al. Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis. Clinical and Experimental Hepatology. 2022;8(4):284-292. doi:10.5114/ceh.2022.120030.

APA

Piedade, J., Guimarães, L., Duarte, J., Gouveia, L., Garfinkel, T.,  & Veiga, Z. et al. (2022). Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis. Clinical and Experimental Hepatology, 8(4), 284-292. https://doi.org/10.5114/ceh.2022.120030

Chicago

Piedade, Juliana, Livia Guimarães, Joana Duarte, Lorena Gouveia, Tamar Garfinkel, Zulane Veiga,  and Camila Alcântara et al. 2022. "Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis". Clinical and Experimental Hepatology 8 (4): 284-292. doi:10.5114/ceh.2022.120030.

Harvard

Piedade, J., Guimarães, L., Duarte, J., Gouveia, L., Garfinkel, T., Veiga, Z., Alcântara, C., Perazzo, H., Fernandes, F.,  and Pereira, G. (2022). Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis. Clinical and Experimental Hepatology, 8(4), pp.284-292. https://doi.org/10.5114/ceh.2022.120030

MLA

Piedade, Juliana et al. "Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis." Clinical and Experimental Hepatology, vol. 8, no. 4, 2022, pp. 284-292. doi:10.5114/ceh.2022.120030.

Vancouver

Piedade J, Guimarães L, Duarte J, Gouveia L, Garfinkel T, Veiga Z et al. Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis. Clinical and Experimental Hepatology. 2022;8(4):284-292. doi:10.5114/ceh.2022.120030.

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Introduction
Data of minimal hepatic encephalopathy (MHE) before and after hepatitis C virus (HCV) treatment remain scarce. We aimed to describe the prevalence, evolution and predictive factors of MHE before and after a sustained virological response (SVR).

Material and methods
It was a prospective study that included adults with cirrhosis due to HCV treated by direct-acting agents (DAA). MHE was assessed using the Psychometric Hepatic Encephalopathy Score (PHES).

Results
104 patients (65% female, age 60 ±10 years; 69% with diabetes, 47% with hypertension; 82% Child-Pugh A) were included. MHE was assessed just before therapy and 12 (IQR 7-15) months after SVR. Prevalence of MHE before HCV treatment and after SVR were 16% and 22%, respectively (p = 0.18). Resolution of MHE after SVR occurred in a few patients (n = 4/17) and 10 of 87 patients (11.5%) without MHE before treatment developed this condition after SVR. MHE after SVR was more common in patients with MHE before treatment (57% vs. 5%, p < 0.001). In multivariate analysis, older age, hypertension and hypoalbuminemia after treat-ment were predictors of MHE after SVR. In the absence of all these variables, none of the patients had MHE. In contrast, the prevalence of MHE was 42% and 70% in the case of presence of any 2 of these factors and all these conditions, respectively.

Conclusions
MHE is frequent in patients with cirrhosis who achieved SVR after DAA. SVR is associated with low probability of resolution of MHE and may not entirely protect patients from developing de novo MHE. Presence of MHE before DAA, older age, hypertension and hypoalbuminemia after SVR were independently associated with this condition.

keywords:

Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis

Juliana Piedade 1 , Livia Guimarães 1 , Joana Duarte 1 , Lorena Gouveia 2 , Tamar Garfinkel 2 , Zulane Veiga 1 , Camila Alcântara 1 , Hugo Perazzo 3 , Flavia Fernandes 1 , Gustavo Pereira 1, 2

hepatic encephalopathy, sustained virologic response, hepatitis C, liver cirrhosis

Juliana Piedade

¹

,

Livia Guimarães

¹

,

Joana Duarte

¹

,

Lorena Gouveia

²

,

Tamar Garfinkel

²

,

Zulane Veiga

¹

,

Camila Alcântara

¹

,

Hugo Perazzo

³

,

Flavia Fernandes

¹

,

Gustavo Pereira

^{1, 2}