Frequency of streptococcal upper respiratory tract infections and HLA-<i>Cw*06</i> allele in 70 patients with guttate psoriasis from northern Poland

Agata Maciejewska-Radomska; Aneta Szczerkowska-Dobosz; Krzysztof Rębała; Joanna Wysocka; Jadwiga Roszkiewicz; Zofia Szczerkowska; Waldemar Placek

doi:10.5114/pdia.2014.40982

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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6/2015
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abstract:

Original paper

**Frequency of streptococcal upper respiratory tract infections and HLA-Cw06* allele in 70 patients with guttate psoriasis from northern Poland**

Agata Maciejewska-Radomska

,

Aneta Szczerkowska-Dobosz

,

Krzysztof Rębała

,

Joanna Wysocka

,

Jadwiga Roszkiewicz

,

Zofia Szczerkowska

,

Waldemar Placek

Postep Derm Alergol 2015; XXXII (6): 455–458

DOI: https://doi.org/10.5114/pdia.2014.40982

Online publish date: 2015/12/11

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AMA

Maciejewska-Radomska A, Szczerkowska-Dobosz A, Rębała K, et al. Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2015;32(6):455-458. doi:10.5114/pdia.2014.40982.

APA

Maciejewska-Radomska, A., Szczerkowska-Dobosz, A., Rębała, K., Wysocka, J., Roszkiewicz, J.,  & Szczerkowska, Z. et al. (2015). Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 32(6), 455-458. https://doi.org/10.5114/pdia.2014.40982

Chicago

Maciejewska-Radomska, Agata, Aneta Szczerkowska-Dobosz, Krzysztof Rębała, Joanna Wysocka, Jadwiga Roszkiewicz, Zofia Szczerkowska,  and Waldemar Placek. 2015. "Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 32 (6): 455-458. doi:10.5114/pdia.2014.40982.

Harvard

Maciejewska-Radomska, A., Szczerkowska-Dobosz, A., Rębała, K., Wysocka, J., Roszkiewicz, J., Szczerkowska, Z.,  and Placek, W. (2015). Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 32(6), pp.455-458. https://doi.org/10.5114/pdia.2014.40982

MLA

Maciejewska-Radomska, Agata et al. "Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 32, no. 6, 2015, pp. 455-458. doi:10.5114/pdia.2014.40982.

Vancouver

Maciejewska-Radomska A, Szczerkowska-Dobosz A, Rębała K, Wysocka J, Roszkiewicz J, Szczerkowska Z et al. Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2015;32(6):455-458. doi:10.5114/pdia.2014.40982.

Introduction: The association of guttate psoriasis with a streptococcal throat infection and HLA-Cw*06 allele is well established in different populations. Nevertheless, only few studies on this form of disease have been performed in the Polish population.

Aim: To analyze the frequencies of streptococcal-induced guttate psoriasis and HLA-Cw*06 allele in 70 patients with guttate psoriasis originating from northern Poland.

Material and methods: Seventy patients with guttate psoriasis and 24 healthy volunteers were enrolled into the study. Both groups were sex- and age-matched. The evidence of streptococcal infection was based on the positive throat swabs and/or elevated ASO titers. The modified method, including PCR-SSP and PCR-RFLP, was applied to HLA-Cw*06 genotyping.

Results: HLA-Cw*06 allele was confirmed in 49 (70%) out of 70 patients, which is significantly higher than in the control population (30%) (p = 0.001). Evidence for streptococcal infection was found in 34 (48.5%) subjects with psoriasis. Twenty-seven of them (79%) carried HLA-Cw*06 allele. In 36 individuals in whom no evidence of streptococcal infection was found, 14 (39%) did not carry HLA-Cw*06 allele.

Conclusions: Our data confirm that HLA-Cw*06 is a major, but not imperative, genetic determinant for guttate psoriasis.

keywords:

Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland

Agata Maciejewska-Radomska , Aneta Szczerkowska-Dobosz , Krzysztof Rębała , Joanna Wysocka , Jadwiga Roszkiewicz , Zofia Szczerkowska , Waldemar Placek

guttate psoriasis, human leukocyte antigen, HLA-Cw*06, streptococcus pyogenes

**Frequency of streptococcal upper respiratory tract infections and HLA-Cw06* allele in 70 patients with guttate psoriasis from northern Poland**

Agata Maciejewska-Radomska

,

Aneta Szczerkowska-Dobosz

,

Krzysztof Rębała

,

Joanna Wysocka

,

Jadwiga Roszkiewicz

,

Zofia Szczerkowska

,

Waldemar Placek

guttate psoriasis, human leukocyte antigen, HLA-Cw06, streptococcus pyogenes*