Gastrointestinal exposed endoscopic full-thickness resection in the era of endoscopic suturing: a retrospective single-center case series

Antonino Granata; Alberto Martino; Michele Amata; Dario Ligresti; Mario Traina

doi:10.5114/wiitm.2021.104496

eISSN: 2299-0054
ISSN: 1895-4588

Videosurgery and Other Miniinvasive Techniques

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2/2021
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abstract:

Original paper

Gastrointestinal exposed endoscopic full-thickness resection in the era of endoscopic suturing: a retrospective single-center case series

Antonino Granata

¹

,

Alberto Martino

²

,

Michele Amata

¹

,

Dario Ligresti

¹

,

Mario Traina

¹

Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS – ISMETT, Palermo, Italy
Department of Gastroenterology and Digestive Endoscopy, AORN “Antonio Cardarelli”, Napoli, Italy

Videosurgery Miniinv 2021; 16 (2): 321–328

DOI: https://doi.org/10.5114/wiitm.2021.104496

Online publish date: 2021/03/15

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Introduction
Exposed endoscopic full thickness resection (EFTR) is a minimally invasive technique that has shown promising efficacy and safety in the removal of both gastrointestinal (GI) submucosal tumors (SMTs) arising from the muscularis propria (MP) and select epithelial tumors (ETs) unsuitable for conventional resection techniques. Given the chance of realizing endosurgical full-thickness suturing, the Endoscopic Suturing System (ESS) can be used to close wall defects in this setting. However, data concerning its use in EFTR are still limited.

Aim
This study was conducted to evaluate the safety and efficacy of exposed EFTR with defect closure using the ESS for the removal of both GI SMTs and select ETs unsuitable for conventional resection techniques.

Material and methods
This was a retrospective, single-center, observational cohort study of patients who underwent GI exposed EFTR.

Results
Seven patients (M : F 6 : 1) with a mean age of 56 ±14.5 years were identified. The indications were MP-originating SMTs of the stomach (n = 2) and duodenum (n = 2), and from submucosa of the rectum (n = 1), and 2 ETs of the rectum. Exposed EFTR and defect closure were successfully performed in 6/7 patients. One case was converted to laparoscopic gastric wedge resection due to technical unfeasibility. We performed an R0 resection in all cases, with the exception of 1 case of rectal EFTR. No macroscopic recurrence was detected at 6-month endoscopic follow-up.

Conclusions
GI exposed EFTR with defect closure by the ESS appears to be feasible, effective, and safe in referral centers. Further studies are necessary to clarify the role of the ESS for post-EFTR wall defect closure.

keywords:

Gastrointestinal exposed endoscopic full-thickness resection in the era of endoscopic suturing: a retrospective single-center case series

Antonino Granata 1 , Alberto Martino 2 , Michele Amata 1 , Dario Ligresti 1 , Mario Traina 1

NOTES, endoscopic full thickness resection, endoscopic suturing system, exposed endoscopic full-thickness resection

Antonino Granata

¹

,

Alberto Martino

²

,

Michele Amata

¹

,

Dario Ligresti

¹

,

Mario Traina

¹