Generalized granuloma annulare

Małgorzata Dominiak; Katarzyna Tomaszewska; Zofia Gerlicz-Kowalczuk; Joanna Narbutt; Ewa Trznadel-Grodzka

doi:10.5114/dr.2019.88258

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

4/2019
vol. 106

Send email

Copy url:

abstract:

Case report

Generalized granuloma annulare

Małgorzata Dominiak

¹

,

Katarzyna A. Tomaszewska

²

,

Zofia Gerlicz-Kowalczuk

¹

,

Joanna Narbutt

¹

,

Ewa Trznadel-Grodzka

¹

Dermatology, Paediatric and Oncologic Dermatology Clinic, Medical University of Lodz, Poland
Psychodermatology Department, Chair of Clinical Immunology and Microbiology, Medical University of Lodz, Poland

Dermatol Rev/Przegl Dermatol 2019, 106, 405-410

DOI: https://doi.org/10.5114/dr.2019.88258

Online publish date: 2019/10/02

View full text Get citation

PlumX metrics:

Introduction
Granuloma annulare belongs to the category of dermatoses characterized by necrobiosis in histopathological examination. The disease concerns mainly people under 30 years old. There are different types of granuloma annulare: localized, generalized and subcutaneous. According to the latest scientific reports, antimalarial drugs take a significant place in the treatment of generalized granuloma annulare.

Objective
To present a case of a patient with generalized granuloma annulare and concomitant clinical signs of necrobiosis lipoidica who was treated with chloroquine with substantial improvement.

Case report
A 54-years-old patient hospitalized at the Dermatology Department because of annular and irregular erythematous-atrophic lesions on upper and lower limbs. Ulcerations were present within the lesions on lower extremities. Histopathology was indicative of granuloma annulare. Treatment with chloroquine resulted in marked improvement.

Conclusions
Generalized types of granuloma annulare are rarely observed and constitute a therapeutic challenge. Antimalarial drugs may be considered as the first-line treatment in generalized granuloma annulare.

keywords:

Generalized granuloma annulare

Małgorzata Dominiak 1 , Katarzyna A. Tomaszewska 2 , Zofia Gerlicz-Kowalczuk 1 , Joanna Narbutt 1 , Ewa Trznadel-Grodzka 1

granuloma annulare, antimalarial drugs, necrobiosis

Małgorzata Dominiak

¹

,

Katarzyna A. Tomaszewska

²

,

Zofia Gerlicz-Kowalczuk

¹

,

Joanna Narbutt

¹

,

Ewa Trznadel-Grodzka

¹