|
Current issue
Archive
About the journal
Editorial board
Abstracting and indexing
Subscription
Contact
Instructions for authors
Publication charge
Ethical standards and procedures
Editorial System
Submit your Manuscript
Without publication fees 
Open access 
Journal integrated with 
|
3/2014
vol. 95 abstract:
Review paper
Genetic predisposition to breast and/or ovarian cancer – focus on the candidate BARD1 gene
Katarzyna Klonowska
,
Magdalena Ratajska
,
Marzena Wojciechowska
,
Piotr Kozlowski
vol. 95(3) C pp. 203-214 C 2014
Online publish date: 2015/10/06
View
full text
Get citation
ENW EndNote
BIB JabRef, Mendeley
RIS Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
Germline mutations affecting the BRCA1 and BRCA2 genes explain 16-40% of breast and/or ovarian cancers aggregated
in families. Besides the BRCA1/2 genes and several genetic factors associated with hereditary syndromes which increase the risk of breast cancer, a considerable fraction of potential breast cancer predisposing factors (-50%) remains unknown. It is presumed that candidate genes, functionally related to the BRCA1/2 genes, may account for some of the missing heritability. The BARD1 gene, which encodes a protein indispensable for BRCA1-mediated tumor suppression function and adequate apoptosis regulation, serves as a candidate breast cancer susceptibility gene. Some initial reports indicated that BARD1 is a plausible target for several pathogenic mutations associated with increased breast and/or ovarian cancer risk. Nonetheless, further mutational studies are necessary to determine the penetrance and role of the BARD1 gene in cancer predisposition. keywords:
BARD1, breast and/or ovarian cancer, familial cancer predisposition, DSB repair genes |
  |
|
Copyright by BioTechnologia |
||
| Hosted by Termedia sp. z o.o. |
