Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation – the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring

Marcin Tkaczyk; Daria Tomczyk; Anna Jander; Sebastian Góreczny; Tomasz Moszura; Paweł Dryżek; Wojciech Krajewski; Ewa Głowacka; Agnieszka Wosiak

doi:10.5114/aic.2018.74357

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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Original paper

Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation – the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring

Marcin Tkaczyk

,

Daria Tomczyk

,

Anna Jander

,

Sebastian Góreczny

,

Tomasz Moszura

,

Paweł Dryżek

,

Wojciech Krajewski

,

Ewa Głowacka

,

Agnieszka Wosiak

Adv Interv Cardiol 2018; 14, 1 (51): 67–74

DOI: https://doi.org/10.5114/aic.2018.74357

Online publish date: 2018/03/22

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AMA

Tkaczyk M, Tomczyk D, Jander A, et al. Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation – the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2018;14(1):67-74. doi:10.5114/aic.2018.74357.

APA

Tkaczyk, M., Tomczyk, D., Jander, A., Góreczny, S., Moszura, T.,  & Dryżek, P. et al. (2018). Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation – the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 14(1), 67-74. https://doi.org/10.5114/aic.2018.74357

Chicago

Tkaczyk, Marcin, Daria Tomczyk, Anna Jander, Sebastian Góreczny, Tomasz Moszura, Paweł Dryżek,  and Wojciech Krajewski et al. 2018. "Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation – the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 14 (1): 67-74. doi:10.5114/aic.2018.74357.

Harvard

Tkaczyk, M., Tomczyk, D., Jander, A., Góreczny, S., Moszura, T., Dryżek, P., Krajewski, W., Głowacka, E.,  and Wosiak, A. (2018). Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation – the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 14(1), pp.67-74. https://doi.org/10.5114/aic.2018.74357

MLA

Tkaczyk, Marcin et al. "Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation – the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 14, no. 1, 2018, pp. 67-74. doi:10.5114/aic.2018.74357.

Vancouver

Tkaczyk M, Tomczyk D, Jander A, Góreczny S, Moszura T, Dryżek P et al. Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation – the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2018;14(1):67-74. doi:10.5114/aic.2018.74357.

Introduction
Diagnosis of contrast induced-nephropathy (CIN) by a classic renal biomarker such as creatinine concentration can be delayed because of various factors that can influence this marker. Changes in new biomarkers such as neutrophil-gelatinase associated lipocalin (NGAL) and cystatin C are postulated to be more sensitive for recognizing patients prone to CIN-acute kidney injury (AKI).

Aim
To investigate the role of NGAL and cystatin C as early biomarkers in the diagnosis of kidney injury after cardiac catheterisation.

Material and methods
The study group consisted of 50 patients with congenital heart malformation admitted for scheduled cardiac catheterisation. The biomarkers serum creatinine, serum NGAL and serum cystatin C were tested at 5 time-points sequentially from start to 48 h after the procedure.

Results
Significant changes were noted during the research in the serum creatinine concentration (p < 0.001) and serum NGAL concentration (p < 0.001). CIN-AKI, diagnosed by the modified Schwartz formula, occurred in 16 (32%) patients after 24 h and in 8 (16%) after 48 h. Subsequent analysis showed that serum creatinine significantly rose in the first 2 h of the study with simultaneous reduction in the eGFR. Maximum growth in serum NGAL occurred at 6 h after contrast administration and then returned to the baseline values at 24 h. Serum cystatin C level did not significantly change during the study.

Conclusions
We observed a transient decrease in eGFR and a rise of serum NGAL after 2 h but NGAL was most pronounced at 6 h after the procedure. The potential role of cystatin C as a biomarker of CIN-AKI was not proved.

keywords:

Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation – the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring

Marcin Tkaczyk , Daria Tomczyk , Anna Jander , Sebastian Góreczny , Tomasz Moszura , Paweł Dryżek , Wojciech Krajewski , Ewa Głowacka , Agnieszka Wosiak

children, cardiac catheterization, contrast-induced acute kidney injury

Marcin Tkaczyk

,

Daria Tomczyk

,

Anna Jander

,

Sebastian Góreczny

,

Tomasz Moszura

,

Paweł Dryżek

,

Wojciech Krajewski

,

Ewa Głowacka

,

Agnieszka Wosiak