Good or bad? Botulinum toxin in hidradenitis suppurativa

Karina Polak; Tomasz Muszyński; Anna Tekielak; Aleksandra Frątczak; Bartosz Miziołek; Beata Bergler-Czop

doi:10.5114/dr.2024.142713

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2024
vol. 111

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abstract:

Review article

Good or bad? Botulinum toxin in hidradenitis suppurativa

Karina Polak

^{1, 2}

,

Tomasz Muszyński

^{3, 4, 5}

,

Anna Tekielak

^{1, 2}

,

Aleksandra Frątczak

²

,

Bartosz Miziołek

²

,

Beata Bergler-Czop

²

Doctoral School, Medical University of Silesia, Katowice, Poland
Department of Dermatology, Medical University of Silesia, Katowice, Poland
Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, Krakow, Poland
1st Department of General and Oncological Surgery, Jagiellonian University Medical College, Krakow, Poland
Department of Vascular Surgery, St. John Grande’s Hospital, Krakow, Poland

Dermatol Rev/Przegl Dermatol 2024, 111, 120-124

DOI: https://doi.org/10.5114/dr.2024.142713

Online publish date: 2024/09/13

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Introduction:
Hidradenitis suppurativa (acne inversa, HS) is a chronic dermatological condition.

Methods:
A review of the literature in Embase and Medline databases from inception to May 2023 was performed to identify 8 studies including 28 patients, in which botulinum toxin was used to treat HS.

Results:
Injections of type A and B toxins at doses from 40 U to 250 U per therapeutic area (axillas, groins, genital area, inner thigh, gluteal folds, gluteal cleft, suprapubic area) were used, applied once or in multiple sessions with few months’ intervals. Positive results including visual improvement, reduction in pain and inflammation, increased mobility, accelerated ability to return to physical activity were noted in all studies. Patients’ scores in the Dermatology Life Quality Index (DLQI) showed positive change, with the effects lasting for several months. No major side effects were observed.

Conclusions:
Long-term efficacy and safety studies on larger groups of patients are needed in order to confirm these promising results.

keywords:

Good or bad? Botulinum toxin in hidradenitis suppurativa

Karina Polak 1, 2 , Tomasz Muszyński 3, 4, 5 , Anna Tekielak 1, 2 , Aleksandra Frątczak 2 , Bartosz Miziołek 2 , Beata Bergler-Czop 2

botulinum toxin, hidradenitis suppurativa, acne inversa

Karina Polak

^{1, 2}

,

Tomasz Muszyński

^{3, 4, 5}

,

Anna Tekielak

^{1, 2}

,

Aleksandra Frątczak

²

,

Bartosz Miziołek

²

,

Beata Bergler-Czop

²