eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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4/2014
vol. 11
 
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abstract:

HEART AND LUNG FAILURE, TRANSPLANTOLOGY
The relationship between late gadolinium enhancement imaging and myocardial biopsy in the evaluation of chronic heart failure patients with suspected myocarditis

Jolanta Nowak
,
Jarosław Wasilewski
,
Edyta Reichman-Warmusz
,
Beata Spinczyk
,
Jan Głowacki
,
Karol Miszalski-Jamka
,
Bożena Szyguła-Jurkiewicz
,
Mateusz Tajstra
,
Arkadiusz Badziński
,
Romuald Wojnicz
,
Lech Poloński

Kardiochirurgia i Torakochirurgia Polska 2014; 11 (4): 404-408
DOI: https://doi.org/10.5114/kitp.2014.47340
Online publish date: 2014/11/30
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Aim: The aim of this study was to assess the relationship between late gadolinium-enhanced (LGE) cardiovascular magnetic resonance (CMR) and immunohistochemical markers of inflammation in patients with heart failure and a reduced ejection fraction (HFrEF).

Material and methods: Endomyocardial biopsy and CMR were performed in 38 consecutive patients (24 males, average age 43.2 ± 6.9 years, New York Heart Association [NYHA] class II) with HFrEF and suspected myocarditis. The immunohistochemical evaluation was done by the En-Vision system using DAKO monoclonal antibodies. The presence of > 14 infiltrating cells together with myocardial damage and ≥ 2 + up-regulation of HLA class II was considered diagnostic for myocarditis. The results of LGE were compared with the immunohistochemical markers of inflammation. All patients underwent coronary angiography.

Results: Twelve out of 38 (31.6%) patients met the immunohistological criteria for the diagnosis of myocarditis. Late gadolinium enhancement was present in 23 of 38 (60.5%) patients, mostly at the interventricular septum. No correlation was found between LGE and immunohistochemistry results (Kendall’s tau; r = 0.21, p = 0.09).

Conclusions: Our study revealed no significant relationship between LGE cardiovascular magnetic resonance imaging and immunohistochemical markers of inflammation in patients with HFrEF.
keywords:

immunohistochemistry, cardiac magnetic resonance, myocarditis, chronic heart failure
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