eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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2/2019
vol. 14
 
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abstract:
Original paper

Helicobacter pylori infection coexisting with intestinal metaplasia is not associated with colorectal neoplasms

Banu Boyuk
1
,
Arif Ozgur
1
,
Hande Atalay
2
,
Aslan Celebi
1
,
Ismail Ekizoglu
1
,
Engin Aykurt
3

  1. Department of Internal Medicine, Istanbul Taksim Education and Research Hospital, Istanbul, Turkey
  2. Department of Internal Medicine, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey
  3. Department of Nursing, Istanbul Taksim Education and Research Hospital, Istanbul, Turkey
Gastroenterology Rev 2019; 14 (2): 133–139
DOI: https://doi.org/10.5114/pg.2019.85897
Online publish date: 2019/07/05
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Introduction
Colorectal cancer is one of the most common cancers and is a major cause of morbidity and mortality in the world and our country. Studies have indicated that there might be a relationship between Helicobacter pylori (Hp) and colorectal neoplasia (CN), although others have not found any relationship.

Aim
To determine whether there is a potential relationship between Hp and CN in our patients.

Material and methods
A total of 314 patients, aged 16–86 years, who underwent gastroscopy and colonoscopy at our department between 2015 and 2017 were evaluated retrospectively. The age, gender, endoscopy results, presence of Hp, complete blood count (CBC), vitamin B12, folic acid, C-reactive protein (CRP), and sedimentation levels of the patients were examined.

Results
CBC, ferritin, vitamin B12, and CRP measurements did not show statistical significance in terms of the presence of Hp (p > 0.05). Folate values of Hp-positive patients were significantly lower than Hp-negative patients (p = 0.007; p < 0.01). No significant relationship was detected between Hp and colon cancer (p > 0.05). Adenomatous polyps were not related to Hp (p > 0.05). Correlation between intestinal metaplasia (IM) and adenomatous polyps was insignificant. There was no statistically significant difference between colon and gastric pathology results.

Conclusions
In our study, no significant relationship was noted between Hp and CN. A few studies have been conducted in our country, and our results are consistent with some of these studies while it is contradictory to others. Large populational multicentre studies are needed in order to identify the relationship between Hp and CN.

keywords:

Helicobacter pylori, colorectal neoplasia, intestinal metaplasia
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