eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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4/2020
vol. 6
 
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abstract:
Original paper

Hepatic interferon γ and tumor necrosis factor a expression in infants with neonatal cholestasis and cytomegalovirus infection

Himali Meshram
1
,
Shilpa Velhal
2
,
Varsha Padwal
2
,
Jyoti Sutar
2
,
Ravi Kadam
2
,
Jacinta Pereira
2
,
Gauri Bhonde
3
,
Kalyani Karandikar
3
,
Vikrant Bhor
3
,
Vainav Patel
3
,
Naman S. Shetty
1
,
Ira Shah
1

  1. Bai Jerbai Wadia Hospital for Children, Mumbai, India
  2. Indian Council of Medical Research (ICMR), New Delhi, India
  3. National Institute for Research in Reproductive Health (NIRRH), Mumbai, India
Clin Exp HEPATOL 2020; 6, 4: 367–373
DOI: https://doi.org/10.5114/ceh.2020.102172
Online publish date: 2020/12/30
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Introduction
To determine the hepatic interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α) levels in infants with neonatal cholestasis (NC) and associated cytomegalovirus (CMV) infection.

Material and methods
This study was conducted in 21 infants with NC over a period of 6 months from June 2017 to December 2017 to determine the hepatic IFN-γ and TNF-α levels in infants with NC and associated CMV infection.

Results
IFN-γ levels were positive in 16 (80%), low positive in 3 (16%) and negative in 1 (5%) patients. High positive and positive TNF-α levels were seen in 9 (56.3%) patients with positive liver CMV PCR and low positive levels were seen in 7 (43.7%) patients with positive liver CMV PCR (odds ratio [OR] = 2.6). Positive IFN-γ was present in 13 (81.3%) patients with positive liver CMV PCR and low positive or negative IFN-γ was seen in 3 (18.7%) patients with positive liver CMV PCR (OR = 2.2). Six (60%) patients with positive or high positive TNF-α levels in liver tissue had biliary atresia (BA) whereas 7 (77.7%) with low positive TNF-α levels had non-BA neonatal hepatitis (OR = 5.25). Six (37.5%) patients with positive IFN-γ had BA whereas 2 (50%) patients with low positive or negative IFN-γ had BA (OR = 0.6).

Conclusions
There is high prevalence of CMV in liver tissues in patients with NC and elevated TNF-α and IFN-γ levels are seen in these patients. Elevated TNF-α is also seen in patients with BA. The association of elevated TNF-α, BA and CMV infection needs to be evaluated further.

keywords:

immunochemistry, CMV, neonatal cholestasis
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