Hepatocellular carcinoma recurrence after directly acting antivirals for chronic hepatitis C: a 2-year follow-up study

Ahmed Kamal; Amr Aly Abd Elmoety; Yousri Abdelmeguid Rostom; Mohamed Said Shater; Sameh Aldesoky Lashen

doi:10.5114/ceh.2021.104397

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Hepatocellular carcinoma recurrence after directly acting antivirals for chronic hepatitis C: a 2-year follow-up study

Ahmed Kamal

¹

,

Amr Aly Abd Elmoety

¹

,

Yousri Abdelmeguid Rostom

²

,

Mohamed Said Shater

¹

,

Sameh Aldesoky Lashen

¹

Hepatology Unit, Internal Medicine Department, Alexandria University, Egypt
Clinical Oncology and Nuclear Medicine Department, Alexandria University, Egypt

Clin Exp HEPATOL 2021; 7, 1: 66-73

DOI: https://doi.org/10.5114/ceh.2021.104397

Online publish date: 2021/03/11

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Aim of the study
Data regarding hepatocellular carcinoma (HCC) recurrence after directly acting antivirals for hepatitis C are contradictory. Our aim was to study the HCC recurrence in patients who received directly acting antivirals after tumor ablation.

Material and methods
This retrospective study included all Child-Pugh A and B patients with hepatitis C related < 5 cm single or up to 3 HCC without any vascular or extrahepatic involvement whose lesions were managed using microwave or radiofrequency ablation at the Internal Medicine Department of Alexandria Faculty of Medicine, in the period from 1 January 2016 to 31 December 2016, and then received directly acting antivirals.

Results
Data from 52 patients were analyzed. Throughout the 2 years from ablation, 42.3% of patients experienced tumor recurrence (22 out of 52 patients). In addition, two subjects died and 4 subjects were lost to follow-up before any tumor recurrence.

Conclusions
Although our study included both modified Child-Pugh A and B patients and included lesions up to 5 cm treated using thermal ablation, the 2-year HCC recurrence rate was similar to that previously reported after surgical resection or radiofrequency ablation of lesions up to 3 cm in Child-Pugh A patients before development of directly acting antivirals.

keywords:

Hepatocellular carcinoma recurrence after directly acting antivirals for chronic hepatitis C: a 2-year follow-up study

Ahmed Kamal 1 , Amr Aly Abd Elmoety 1 , Yousri Abdelmeguid Rostom 2 , Mohamed Said Shater 1 , Sameh Aldesoky Lashen 1

hepatocellular carcinoma, chronic hepatitis C, antiviral agents, liver cirrhosis, neoplasm recurrence

Ahmed Kamal

¹

,

Amr Aly Abd Elmoety

¹

,

Yousri Abdelmeguid Rostom

²

,

Mohamed Said Shater

¹

,

Sameh Aldesoky Lashen

¹