Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis

Halina Cichoż-Lach; Beata Prozorow-Król; Jarosław Swatek; Barbara Skrzydło-Radomańska; Leszek Buk; Małgorzata Zdunek; Agnieszka Kowalik; Maria Słomka

doi:10.5114/pg.2014.40853

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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1/2014
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abstract:

Case report

Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis

Halina Cichoż-Lach

,

Beata Prozorow-Król

,

Jarosław Swatek

,

Barbara Skrzydło-Radomańska

,

Leszek Buk

,

Małgorzata Zdunek

,

Agnieszka Kowalik

,

Maria Słomka

Prz Gastroenterol 2014; 9 (1): 57–61

DOI: https://doi.org/10.5114/pg.2014.40853

Online publish date: 2014/03/01

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AMA

Cichoż-Lach H, Prozorow-Król B, Swatek J, et al. Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis. Gastroenterology Review/Przegląd Gastroenterologiczny. 2014;9(1):57-61. doi:10.5114/pg.2014.40853.

APA

Cichoż-Lach, H., Prozorow-Król, B., Swatek, J., Skrzydło-Radomańska, B., Buk, L.,  & Zdunek, M. et al. (2014). Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis. Gastroenterology Review/Przegląd Gastroenterologiczny, 9(1), 57-61. https://doi.org/10.5114/pg.2014.40853

Chicago

Cichoż-Lach, Halina, Beata Prozorow-Król, Jarosław Swatek, Barbara Skrzydło-Radomańska, Leszek Buk, Małgorzata Zdunek,  and Agnieszka Kowalik et al. 2014. "Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis". Gastroenterology Review/Przegląd Gastroenterologiczny 9 (1): 57-61. doi:10.5114/pg.2014.40853.

Harvard

Cichoż-Lach, H., Prozorow-Król, B., Swatek, J., Skrzydło-Radomańska, B., Buk, L., Zdunek, M., Kowalik, A.,  and Słomka, M. (2014). Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis. Gastroenterology Review/Przegląd Gastroenterologiczny, 9(1), pp.57-61. https://doi.org/10.5114/pg.2014.40853

MLA

Cichoż-Lach, Halina et al. "Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis." Gastroenterology Review/Przegląd Gastroenterologiczny, vol. 9, no. 1, 2014, pp. 57-61. doi:10.5114/pg.2014.40853.

Vancouver

Cichoż-Lach H, Prozorow-Król B, Swatek J, Skrzydło-Radomańska B, Buk L, Zdunek M et al. Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis. Gastroenterology Review/Przegląd Gastroenterologiczny. 2014;9(1):57-61. doi:10.5114/pg.2014.40853.

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Amyloidosis is characterised by the accumulation of poorly soluble fibrous proteins in the extracellular space of various bodily organs. Light chain amyloidosis (AL) is recognised as the most common form of systemic amyloidosis. Light chains are deposited in the majority of bodily organs, and accumulation of them in the liver produces hepatomegaly. We report a case of AL-systemic amyloidosis with liver involvement in a 71-year-old woman. Hepatomegaly, weight loss and general malaise were the first manifestations of the disease. Liver biopsy found amyloid deposits along the sinusoids as well as in the space of Disse, inside the vascular wall and in connective tissue of the portal tracts, which showed a positive reaction in Congo Red stain. Further diagnosis showed the presence of systemic amyloidosis. The patient was put on cyclophosphamide and steroid therapy.

keywords:

Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis

Halina Cichoż-Lach , Beata Prozorow-Król , Jarosław Swatek , Barbara Skrzydło-Radomańska , Leszek Buk , Małgorzata Zdunek , Agnieszka Kowalik , Maria Słomka

amyloidosis, histological diagnosis, hepatomegaly

Halina Cichoż-Lach

,

Beata Prozorow-Król

,

Jarosław Swatek

,

Barbara Skrzydło-Radomańska

,

Leszek Buk

,

Małgorzata Zdunek

,

Agnieszka Kowalik

,

Maria Słomka