eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
2/2014
vol. 9
 
Share:
Send email
Share:
abstract:
Case report

Hepatotoxicity caused by montelukast in a paediatric patient

Dariusz M. Lebensztejn
,
Anna Bobrus-Chociej
,
Monika Kłusek
,
Miroslawa Uscinowicz
,
Joanna Lotowska
,
Maria Sobaniec-Lotowska
,
Maciej Kaczmarski

Prz Gastroenterol 2014; 9 (2): 121–123
DOI: https://doi.org/10.5114/pg.2014.42509
Online publish date: 2014/05/05
View full text Get citation
 
PlumX metrics:
Montelukast is a selective and competitive cysteinyl leukotriene receptor antagonist (CystLTRA) which is increasingly used for the treatment of allergic asthma. Recently, hepatotoxicity has been reported with this drug in adult patients, but only one letter to the editor has reported a case of probable montelukast-induced hepatotoxicity in a child. We present a case of a 3.5-year-old boy, receiving treatment with montelukast, who developed hepatocellular injury. The exclusion of other causes of increased activity of aminotransferases (viral, metabolic, autoimmune), improvement after dechallenge, the morphological findings and previous reports of comparable cases support the diagnosis of montelukast-induced liver injury in this boy. Physicians should strictly analyse indications for this drug and be aware of potential drug-induced liver disease caused by this agent. Therefore, the periodical assessment of aminotransferases should be recommended during treatment with this leukotriene modifier.
keywords:

montelukast, hepatotoxicity, drug-induced liver disease, children
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.