|
abstract:
Original paper
Higher physical activity levels are related to faecal microbiota
diversity and composition in young adults
Lourdes Ortiz-Alvarez
1, 2
,
Samuel Ruiz-Campos
3, 4
,
Francisco M. Acosta
1, 5, 6, 7
,
Ramiro Vilchez-Vargas
9
,
Julio Plaza-Díaz
2, 10, 11
,
Angel Gil
2, 11, 12, 13
,
Borja Martinez-Tellez
1, 3, 4, 15
- PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Sport and Health University
Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University
of Granada, Granada, Spain
- Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain
- Department of Nursing, Physiotherapy and Medicine and SPORT Research Group (CTS-1024), CERNEP Research
Center, University of Almería, Almería, Spain
- Biomedical Research Unit, Torrecárdenas University Hospital, Almería, 04009, Spain
- Turku PET Centre, University of Turku, Turku, Finland
- Turku PET Centre, Turku University Hospital, Turku, Finland
- InFLAMES Research Flagship Center, University of Turku, Turku, Finland
- Department of Biosciences and Nutrition, Karolinska Institute, Karolinska, Sweden
- Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University Magdeburg,
Magdeburg, Germany
- Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada
- Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, Parque Tecnológico Ciencias
de la Salud, University of Granada, Armilla, Granada, Spain
- CIBEROBN, Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition, Carlos III
Health Institute, Madrid, Spain
- Instituto de Investigación Biosanitaria, ibs.Granada, Granada, Spain
- Institute for Sustainability & Food Chain Innovation (ISFOOD), Department of Health Sciences, Public University
of Navarra, Campus de Arrosadía, Pamplona, Spain
- Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine,
Leiden University Medical Center, Leiden, The Netherlands
Biol Sport. 2025;42(1):123–135
Online publish date: 2024/06/04
PlumX metrics:
Increasing physical activity (PA) is recognised as an efficacious approach for preventing and treating cardiometabolic diseases. Recently, the composition of microorganisms living within the gut has been proposed as an important appropriate target for treating these diseases. Whether PA is related to faecal microbiota diversity and composition in humans remains to be ascertained. Thus, we examined the association of the time spent in objectively measured PA with faecal microbiota diversity and composition in young adults. A cross-sectional study enrolled 88 young adults aged 22.0 ± 2.3 years (72.7% women), whose time spent in PA at different intensities was objectively measured with a wrist-worn accelerometer for 7 consecutive days. Faecal microbiota diversity and composition were analysed with hypervariable tag sequencing of the V3–V4 region of the 16S rRNA gene. The mean Euclidean Norm of the raw accelerations Minus One (mg) during waking time, considered as overall PA, and the time spent in vigorous PA were positively correlated with alpha diversity indexes (all rho ≥ 0.23, P ≤ 0.034). Regarding faecal microbiota composition, participants with low time spent in vigorous PA had higher relative abundance of the Gammaproteobacteria class (q = 0.021, FDR = q-value) compared to the participants with high time spent in vigorous PA, and lower relative abundance of the Porphyromonadaceae family (q = 0.031) and the Alistipes genus (q = 0.015) compared to the individuals with high and intermediate time spent in vigorous PA, respectively. Our results suggest that PA, especially of vigorous intensity, is related to faecal microbiota diversity and the Gammaproteobacteria class and Porphyromonadaceae family in young adults.
keywords:
Physical activity, Gastrointestinal microbiome, Shorts-chain fatty acids, Obesity, Activity monitor
|
|
