Histological heterogeneity and distributional difference of gastric carcinosarcoma: report of 4 cases and literature review

Ling Nie; Xiaoli Zhou; Lijun Peng; Yao Fu; Yuqing Cheng; Qin Huang

doi:10.5114/pjp.2018.81696

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

4/2018
vol. 69

Send email

Copy url:

abstract:

Original paper

Histological heterogeneity and distributional difference of gastric carcinosarcoma: report of 4 cases and literature review

Ling Nie

,

Xiaoli Zhou

,

Lijun Peng

,

Yao Fu

,

Yuqing Cheng

,

Qin Huang

Pol J Pathol 2018; 69 (4): 366-375

DOI: https://doi.org/10.5114/pjp.2018.81696

Online publish date: 2019/01/31

View full text Get citation

PlumX metrics:

Carcinosarcoma is a rare malignant neoplasm, consisting of both epithelial and mesenchymal component. Primary gastric carcinosarcoma is rare and poorly understood. We reported clinicopathologic features of 4 cases and analysis of 76 cases published in the literature. Clinical symptoms were nonspecific with epigastric pain, weight loss, and melena, as the most common complaints. The prognosis of patients was dismal with high mortality. The tumor commonly occurred in the upper stomach in Chinese patients, whereas, it was more prevalent at the lower stomach in Japanese and other populations. The two malignant components of this rare cancer showed considerable histological heterogeneity with a wide range of differentiation. We propose that carcinosarcomas be divided in two main subtypes: conventional carcinosarcoma and carcinosarcoma, not-otherwise-specified (NOS). Such distinction may provide useful information for targeted treatment of various sarcomatous components of this tumor. Immunohistochemistry should be routinely applied in the diagnosis of this rare tumor.

keywords:

Histological heterogeneity and distributional difference of gastric carcinosarcoma: report of 4 cases and literature review

Ling Nie , Xiaoli Zhou , Lijun Peng , Yao Fu , Yuqing Cheng , Qin Huang

stomach, carcinosarcoma, gastric cardia, classification

Ling Nie

,

Xiaoli Zhou

,

Lijun Peng

,

Yao Fu

,

Yuqing Cheng

,

Qin Huang