Histopathological assessment of oral leukoplakia. Osteonectin as possible biomarker for further diagnostics

Irena Duś-Ilnicka; Małgorzata Radwan-Oczko; Hanna Gerber; Agnieszka Hałoń

doi:10.5114/pjp.2020.97021

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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2/2020
vol. 71

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abstract:

Original paper

Histopathological assessment of oral leukoplakia. Osteonectin as possible biomarker for further diagnostics

Irena Duś-Ilnicka

¹

,

Małgorzata Radwan-Oczko

¹

,

Hanna Gerber

²

,

Agnieszka Hałoń

³

Oral Pathology Department, Faculty of Dentistry, Wroclaw Medical University, Wroclaw, Poland
Department and Clinic of Maxillofacial Surgery, Faculty of Dentistry, Wroclaw Medical University, Wroclaw, Poland
Department of Pathomorphology and Oncological Cytology, Faculty of Dentistry, Wroclaw Medical University, Wroclaw, Poland

Pol J Pathol 2020; 71 (2): 138-145

DOI: https://doi.org/10.5114/pjp.2020.97021

Online publish date: 2020/07/21

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Clinical evaluation of oral leukoplakia (OL), confirmed by the histological evaluation of the suspected area, provides the gold standard for diagnostics of this pathology. The aim of present study was to encrypt the significance of the histopathological results (oral intraepithelial neoplasia – OIN, WHO 2005, Ljubljana classification systems) of OL. The usefulness of osteonectin as a biomarker of changes in the oral cavity epithelium was evaluated.

IRS Score to evaluate osteonectin (SPARC – secreted protein acidic and rich in cysteine) production in oral mucous tissues was modified, with the aim of adapting the diagnostic measurements to the OL cell environment. In total, 37 formalin-fixed, paraffin-embedded (FFPE) blocks from patients with clinically diagnosed OL, and 29 FFPE blocks from patients with OSCC were evaluated. The OIN and system from Ljubljana were compared, to adjudicate which was most compatible with WHO 2005 histopathological assessment.

Increased production of SPARC was observed, with the progression in severity of pathological changes in the oral mucosa, from simple hyperplasia, through dysplasia, to OSCC. The WHO 2005 and the OIN classification systems can be applied interchangeably.

keywords:

Histopathological assessment of oral leukoplakia. Osteonectin as possible biomarker for further diagnostics

Irena Duś-Ilnicka 1 , Małgorzata Radwan-Oczko 1 , Hanna Gerber 2 , Agnieszka Hałoń 3

osteonectin, SPARC, oral leukoplakia, oral neoplasms

Irena Duś-Ilnicka

¹

,

Małgorzata Radwan-Oczko

¹

,

Hanna Gerber

²

,

Agnieszka Hałoń

³