eISSN: 2299-551X
ISSN: 0011-4553
Journal of Stomatology
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

2/2021
vol. 74
 
Share:
Send email
Share:
abstract:
Original paper

Hyaluronic acid 0.2% application enhanced periodontitis treatment in non-surgical phase

Thuy T. Nguyen
1
,
Hoa T. Ho
1
,
Nam C. Huynh
2
,
Vu H.A. Dien
3
,
Thuy L. Vo
4

  1. Department of Periodontology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
  2. Department of Dental Basic Sciences, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
  3. Department of Dental Public Health, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
  4. Department of Implantology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
J Stoma 2021; 74, 2: 76-83
DOI: https://doi.org/10.5114/jos.2021.106571
Online publish date: 2021/06/14
View full text Get citation
 
PlumX metrics:
Introduction
Topical hyaluronic acid (HA) has been considered as an adjuvant agent for periodontitis (PD). Objectives: This study aimed to assess the clinical effects of subgingival application of 0.2% HA gel, following scaling and root planning (SRP) in PD patients.

Material and methods
In this randomized split-mouth study, 733 periodontal pockets of 28 patients with PD were investigated. They were divided into control and experimental groups. The experimental group received subgingival administration of 1 ml 0.2% HA gel into each pocket immediately after SRP, and then after 1 week, 2 weeks, and 3 weeks. Clinical parameters and subgingival plaque were assessed at baseline and 6 weeks after SRP. Quantitative real-time polymerase chain reaction for Porphyromonas gingivalis (Pg), Treponema denticola (Td), Fusobacterium nucleatum (Fn), and Tannerella forsythia (Tf) were also performed.

Results
After 6 weeks, there were significant decreases in clinical parameters, and the number of Fn in the expe­rimental group compared to the control group (p < 0.05). The number of Pg, Td, and Tf decreased significantly in both groups, with no significant difference between the 2 cohorts (p > 0.05).

Conclusions
he topical application of HA gel in periodontal pockets after SRP may have a beneficial effect in PD patients. This additional treatment appears to help reducing 2 types of bacteria (Tf and Fn) better than non-surgical treatment only.

keywords:

chronic periodontitis, adjunctive therapy, hyaluronic acid, bactericidal efficiency, clinical parame­ters

  
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.