Hypoxia in uterine cervical cancer: impact on treatment

Janina Markowska; Radosław Mądry; Jacek Grabowski; Karolina Jaszczyńska-Nowinka,; Monika Szarszewska

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2008
vol. 12

Send email

Copy url:

abstract:

Hypoxia in uterine cervical cancer: impact on treatment

Janina Markowska

,

Radosław Mądry

,

Jacek Grabowski

,

Karolina Jaszczyńska-Nowinka,

,

Monika Szarszewska

Współczesna Onkologia (2008) vol. 12; 1 (11–15)

Online publish date: 2008/03/20

View full text Get citation

Rapid proliferation of tumour results in production of pro-angiogenic factors due to tissue hypoxia. However, the new abnormal blood supply cannot provide correct oxygenation, so low oxygen tension remains, causing resistance to radio-/chemotherapy and increasing the risk of metastases. There are known substances, hypoxia markers, whose level significantly increases in oxygen deficiency. They are: HIF-1a (hypoxia inducible factor 1a), CA9 (carboanhydrase 9) and GLUT1 (glucose transporter 1). It is proved that among patients at the same stage of cervical cancer, women with high hypoxia markers’ expression have shorter disease-free survival and overall survival time. Many attempts have been made to use hypoxia in target therapy by introducing modified radio-/chemotherapy schemes, 2C3 antibodies, which block VEGF, YC-1 inactivating HIF-1a and bortezomib, a proteasome inhibitor responsible for blocking angiogenesis and apoptosis promotion. It is believed that routine examination of hypoxia markers may allow in future the planning of treatment adjusted individually to every patient.

keywords:

Hypoxia in uterine cervical cancer: impact on treatment

Janina Markowska , Radosław Mądry , Jacek Grabowski , Karolina Jaszczyńska-Nowinka, , Monika Szarszewska

cervical cancer, hypoxia markers, hypoxia

Janina Markowska

,

Radosław Mądry

,

Jacek Grabowski

,

Karolina Jaszczyńska-Nowinka,

,

Monika Szarszewska