eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
2/2019
vol. 70
 
Share:
Send email
Share:
abstract:
Original paper

Hypoxia-inducible factor 1α in combination with vascular endothelial growth factor could predict the prognosis of postoperative patients with oesophageal squamous cell cancer

Jing-Bo Shao
1, 2
,
Zhe Li
3
,
Nan Zhang
4
,
Fei Yang
5
,
Wei Gao
5
,
Zhi-Gang Sun
6

  1. Weifang Medical University, Weifang, People’s Republic of China
  2. Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, People’s Republic of China
  3. Department of Medical Examination, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, People’s Republic of China
  4. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, People’s Republic of China
  5. Department of Pathology, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, People’s Republic of China
  6. Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, People’s Republic of China
Pol J Pathol 2019; 70 (2): 84-90
DOI: https://doi.org/10.5114/pjp.2019.87100
Online publish date: 2019/08/28
View full text Get citation
 
PlumX metrics:
The purpose of the study is to investigate the clinicopathological and prognostic features of dual hypoxia-inducible factor 1a (HIF-1a) and vascular endothelial growth factor (VEGF) expression in oesophageal squamous cell carcinoma (OSCC) patients. A total of 73 patients were enrolled in this study. The positive expression of HIF-1a was identified in 69.9% of the cases. Hypoxia-inducible factor 1a expression was correlative with pT (p = 0.008) and pTNM stage (p = 0.002). The positive expression of VEGF was identified in 63.0% of the cases. Vascular endothelial growth factor expression was correlative with pT (p = 0.005), pN (p = 0.045), and pTNM stage (p < 0.05). HIF-1a and VEGF expressions had a significantly positive correlation (p = 0.010). Dual positive expression of HIF-1a and VEGF was identified in 50.7% (37/73) of the cases, and it was significantly correlative with pT (p = 0.025), pN (p = 0.008), and pTNM stage (p = 0.014). The OSCC patients’ 5-year survival rate was correlative with pT (p < 0.05), pN (p < 0.01), pTNM stage (p < 0.01), VEGF expression (p < 0.01), and dual expressions of HIF-1a and VEGF (p < 0.01). Cox regression analysis showed that pN and dual HIF-1a and VEGF expression were independent prognostic factors for the 5-year survival rate of the patients. In conclusion, HIF-1a combined with VEGF could enable us to more accurately predict the prognosis of OSCC patients.
keywords:

oesophageal squamous cell cancer, HIF-1a, VEGF, immunohistochemistry
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.