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ISSN: 2353-6942
Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO
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abstract:
Original paper

INVESTIGATION OF GST AND DRUG RESISTANCE PROTEIN EXPRESSIONS IN RELATION TO CHEMOTHERAPY IN BREAST CANCER

Arzu Kaya Kocdogan
1
,
Murat Kilic
2
,
Serpil Oguztuzun
3
,
Emine Benzer
4
,
Gulay Dilek
4
,
Yavuz Selim Kahraman
5
,
Mehmet Ali Gulcelık
6

  1. Department of Pathology Laboratory Techniques, Vocational School of Health Services, Istanbul Gelisim University, Istanbul, Türkiye
  2. Department of Pharmacy Services Ankara, Vocational School of Health Services, Ankara University, Türkiye
  3. Department of Biology, Faculty of Engineering and Natural Sciences, Kırıkkale University, Kırıkkale, Türkiye
  4. Department of Pathology, Dr. Abdurrahman Yurtaslan Ankara Oncology Research and Education Hospital, Ankara, Türkiye
  5. Department of Surgical Oncology, Kastamonu Research and Training Hospital, Kastamonu, Türkiye
  6. Department of General Surgery, Gulhane Research and Training Hospital, Ankara, Türkiye
Health Prob Civil
DOI: https://doi.org/10.5114/hpc.2024.139094
Online publish date: 2024/05/08
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Background
During cancer therapy, resistance to chemotherapeutic agents is common and often linked to multidrug resistance mechanisms. Glutathione S-transferases (GSTs) and ATP-binding cassette (ABC) transporters, including multidrug resistance (MDR) proteins, multidrug resistance-associated proteins (MRPs), and breast cancer resistance protein (BCRP), are implicated in drug resistance.

Material and methods
Protein expressions were determined in the tumor and surrounding tumor free breast tissues of 145 breast cancer patients by immunohistochemistry technique. Among 145 patients, 50 received preoperative (neoadjuvant) chemotherapy, and 95 received postoperative (adjuvant) chemotherapy.

Results
In 50 neoadjuvant breast cancer patients, GSTA1, GSTK1, GSTM1, GSTO1, GSTP1, GSTS1, GSTT1, GSTZ1, MDR1, MRP1, MRP2, MRP3, MRP7, and BCRP expressions were higher in tumor epithelium compared to normal epithelium (p<0.05). In 95 adjuvant breast cancer patients, GSTA1, GSTK1, GSTM1, GSTP1, GSTT1, GSTZ1, MDR1, MRP1, MRP2, and MRP3 expressions were higher in tumor epithelium than in normal epithelium (p<0.05). GSTP1, GSTT1, and MRP3 expressions were significantly higher in neoadjuvant compared to adjuvant-treated breast cancer patients’ tumor tissues (p<0.05).

Conclusions
GSTP1, GSTT1, and MRP3 may be important in inactivating the chemotherapeutic agents used in platinum-based treatment and are thus responsible for the drug resistance in breast cancer patients.

keywords:

multidrug resistance, GST, drug resistance, breast cancer, chemotherapy

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