eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2019
vol. 44
 
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abstract:
Case report

IgA nephropathy associated with coeliac disease

Ireneusz Habura
1
,
Katarzyna Fiedorowicz
1
,
Aldona Woźniak
2
,
Ilona Idasiak-Piechocka
3
,
Paweł Kosikowski
2
,
Andrzej Oko
3

  1. Department of Nephrology, Karol Marcinkowski Hospital, Zielona Góra, Poland
  2. Department of Clinical Pathology, University of Medical Sciences, Poznań, Poland
  3. Department of Nephrology, Transplantology and Internal Medicine, University of Medical Sciences, Poznań, Poland
(Centr Eur J Immunol 2019; 44 (1): 106-108)
DOI: https://doi.org/10.5114/ceji.2019.84021
Online publish date: 2019/04/15
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Coeliac disease (CD) is an autoimmune disorder of the small intestine triggered by ingested gluten from barley, rye and wheat. It can be associated with other autoimmune conditions, such as type 1 diabetes, autoimmune thyroiditis and hepatitis, Sjögren’s syndrome and IgA nephropathy (IgAN). We describe here a case of a 24-year-old man with the above-mentioned atypical form of coeliac disease for whom the diagnosis started with renal disorder. The diagnosis of nephrotic syndrome was established and the coexistence with CD was also suspected. In fact, immunoglobulin (Ig) A and IgG antibodies against endomysium and against gliadin were detected in serum of the patient and the endoscopic biopsy of the duodenum revealed stage 3B CD. Percutaneous kidney biopsy was also performed. Class I IgAN was diagnosed. Gluten-free diet, ACE inhibitor and oral iron were introduced to the patient. The improvement of clinical and laboratory disorders of CD as well as gradual remission of the nephrotic syndrome were observed. In conclusion, there may be a small group of patients with IgAN coexisting with CD in whom a gluten-free diet seems to be the treatment of choice for the resolution of kidney disease.
keywords:

IgA nephropathy, gluten-free diet, coeliac disease
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