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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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Letter to the Editor

Imatinib-induced hard palate mucosal discoloration in patients with gastrointestinal stromal tumour (GIST) and dermatofibrosarcoma protuberans (DFSP): a case series of three patients and literature review

Katarzyna Stawarz
1
,
Jakub Zwolinski
1
,
Adam Galazka
1
,
Anna Gorzelnik
1
,
Karolina Bienkowska-Pluta
1
,
Monika Durzynska
2

  1. Head and Neck Cancer Department, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
  2. Department of Pathology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
Adv Dermatol Allergol 2024; XLI (6): 639-642
DOI: https://doi.org/10.5114/ada.2024.144421
Online publish date: 2024/12/24
Article file
- Imatinib.pdf  [0.15 MB]
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1. Dong Y, Jia L, Wang X, et al. Selective inhibition of PDGFR by imatinib elicits the sustained activation of ERK and downstream receptor signaling in malignant glioma cells. Int J Oncol 2011; 38: 555-69.
2. Antonescu C. Targeted therapy of cancer: new roles for pathologists in identifying GISTs and other sarcomas. Mod Pathol 2008; 21 (Suppl 2): S31-6.
3. Alharbi B, Alamri S, Mahdi A, Marghalani S. Dasatinib-induced hypopigmentation in pediatric patient with chronic myeloid leukemia: a case report and review of the literature. Case Rep Dermatol Med 2018; 2018: 4062431.
4. Mascitti M, Luconi E, Togni L, et al. Imatinib-related hyperpigmentation of oral mucosa: case report and literature review. J Dent Sci 2019; 14: 335-7.
5. Li CC, Malik SM, Blaeser BF, et al. Mucosal pigmentation caused by imatinib: report of three cases. Head Neck Pathol 2012; 6: 290-5.
6. Huang X, Patel S, Ahmed N, et al. Severe toxicity of skin rash, fever and diarrhea associated with imatinib: case report and review of skin toxicities associated with tyrosine kinase inhibitors. Drug Des Devel Ther 2009; 2: 215-9.
7. Valeyrie L, Bastuji-Garin S, Revuz J, et al. Adverse cutaneous reactions to imatinib (STI-571) in Philadelphia chromosome positive leukemias: a prospective study of 54 patients. J Am Acad Dermatol 2003; 48: 201-6.
8. Oliveira SR, de Azevedo Branco LG, Rocha AL, et al. Association of oral mucosa hyperpigmentation with imatinib mesylate use: a cross-sectional study and a systematic literature review. Clin Oral Investig 2019; 23: 4371.
9. Patel S, Zalcberg JR. Optimizing the dose of imatinib for treatment of gastrointestinal stromal tumours: lessons from the phase 3 trials. Eur J Cancer 2008; 44: 501-9.
Copyright: © 2024 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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