eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2022
vol. 73
 
Share:
Share:
abstract:
Original paper

Immunohistochemical expression of PARP-1 in triple-negative endometrial cancer – a comparison of different score systems

Michał Bulsa
1
,
Sylwia Romana Jankowska-Szabłowska
2
,
Elżbieta Urasińska
2

  1. Obstetrics and Gynecology Department with the Oncological Gynecology and Infertility Diagnostics and Treatment Sub-Departments, Multidisciplinary Provincial Hospital, Gorzów Wielkopolski, Poland
  2. Department of Pathology, Pomeranian Medical University, Szczecin, Poland
Pol J Pathol 2022; 73 (4): 330-337
Online publish date: 2023/03/09
View full text Get citation
 
PlumX metrics:
Endometrial cancer is the most common malignant neoplasm of the female reproductive system. The number of diagnosed cases is increasing every year. In recent years, the triple-negative phenomenon (TNP) has been identified as one of the determinants of shorter survival in endometrial cancer patients. The aim of the study was to compare the PARP-1 protein expression in triple-negative (TNEC) and non-triple-negative (NTNEC) endometrial cancer patients and determine the relationship between the PARP-1 protein expression in endometrial cancer cells and patient’s overall survival depending on the adopted scale (H-SCORE < 75, H-SCORE < 50, Allred scale).

The study involved 265 patients with histopathologically confirmed endometrial cancer. The patients were divided into 2 groups: patients with TNEC and patients with NTNEC. The study was conducted using a tissue microarray technique. Expression of PARP-1 protein was determined by immunohistochemistry.

Protein expression evaluation was performed using virtual microscopy and the Image Scope computer image analysis system.

The following conclusions were reached: total and individual levels of nuclear or cytoplasmic PARP-1 expression varied with the presence or absence of TNP, and PARP-1 nuclear expression at the 2+ level had a significant effect on the increased risk of death (according to H-SCORE < 75).
keywords:

endometrial cancer, PARP-1, triple-negative cancer

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.