Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity

Kelvin Manuel Pińa Batista; Kenia Yoelvi Alvarez Reyes; Fátima Pérez Lopez; Andrés Coca Pelaz; Ivan Fernandez Vega; José Luis Llorente Pendás; Antonio Saiz Ayala; Aurora Astudillo; Jorge Andrés Nuńez Rojas; Patricia Barrio Fernandez

doi:10.5114/wo.2017.72385

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2017
vol. 21

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abstract:

Review paper

Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity

Kelvin Manuel Pińa Batista

,

Kenia Yoelvi Alvarez Reyes

,

Fátima Pérez Lopez

,

Andrés Coca Pelaz

,

Ivan Fernandez Vega

,

José Luis Llorente Pendás

,

Antonio Saiz Ayala

,

Aurora Astudillo

,

Jorge Andrés Nuńez Rojas

,

Patricia Barrio Fernandez

Contemp Oncol (Pozn) 2017; 21 (4): 267-273

DOI: https://doi.org/10.5114/wo.2017.72385

Online publish date: 2017/12/30

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AMA

Batista K, Reyes K, Lopez F, et al. Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity. Contemporary Oncology/Współczesna Onkologia. 2017;21(4):267-273. doi:10.5114/wo.2017.72385.

APA

Batista, K., Reyes, K., Lopez, F., Pelaz, A., Vega, I.,  & Pendás, J. et al. (2017). Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity. Contemporary Oncology/Współczesna Onkologia, 21(4), 267-273. https://doi.org/10.5114/wo.2017.72385

Chicago

Batista, Kelvin Manuel Pińa, Kenia Yoelvi Alvarez Reyes, Fátima Pérez Lopez, Andrés Coca Pelaz, Ivan Fernandez Vega, José Luis Llorente Pendás,  and Antonio Saiz Ayala et al. 2017. "Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity". Contemporary Oncology/Współczesna Onkologia 21 (4): 267-273. doi:10.5114/wo.2017.72385.

Harvard

Batista, K., Reyes, K., Lopez, F., Pelaz, A., Vega, I., Pendás, J., Ayala, A., Astudillo, A., Rojas, J.,  and Fernandez, P. (2017). Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity. Contemporary Oncology/Współczesna Onkologia, 21(4), pp.267-273. https://doi.org/10.5114/wo.2017.72385

MLA

Batista, Kelvin Manuel Pińa et al. "Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity." Contemporary Oncology/Współczesna Onkologia, vol. 21, no. 4, 2017, pp. 267-273. doi:10.5114/wo.2017.72385.

Vancouver

Batista K, Reyes K, Lopez F, Pelaz A, Vega I, Pendás J et al. Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity. Contemporary Oncology/Współczesna Onkologia. 2017;21(4):267-273. doi:10.5114/wo.2017.72385.

PlumX metrics:

Chordomas are rare and low-grade malignant solid tumours, despite their histologically benign appearance, that arise in the bone from embryonic notochordal vestiges of the axial skeleton, a mesoderm-derived structure that is involved in the process of neurulation and embryonic development. Chordomas occurring in the skull base tend to arise in the basiocciput along the clivus. Three major morphological variants have been described (classical, chondroid, and atypical/dedifferentiated). The pathogenesis and molecular mechanisms involved in chordoma development remain uncertain. From a pathological standpoint, the microenvironment of a chordoma is heterogeneous, showing a dual epithelial-mesenchymal differentiation. These tumours are characterised by slow modality of biologic growth, local recurrence, low incidence of metastasis rates, and cancer stem cell (CSC) phenotype. The main molecular findings are connected with brachyury immunoexpression and activation of the downstream Akt and mTOR signalling pathways. The differentiation between typical and atypical chordomas is relevant because the tumoural microenvironment and prognosis are partially different. This review provides an insight into the recent and relevant concepts and histochemical markers expressed in chordomas, with special emphasis on dedifferentiated chordomas and their prognostic implications.

keywords:

Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity

Kelvin Manuel Pińa Batista , Kenia Yoelvi Alvarez Reyes , Fátima Pérez Lopez , Andrés Coca Pelaz , Ivan Fernandez Vega , José Luis Llorente Pendás , Antonio Saiz Ayala , Aurora Astudillo , Jorge Andrés Nuńez Rojas , Patricia Barrio Fernandez

dedifferentiated, chordoma, skull base, immunophenotypic, tumor

Kelvin Manuel Pińa Batista

,

Kenia Yoelvi Alvarez Reyes

,

Fátima Pérez Lopez

,

Andrés Coca Pelaz

,

Ivan Fernandez Vega

,

José Luis Llorente Pendás

,

Antonio Saiz Ayala

,

Aurora Astudillo

,

Jorge Andrés Nuńez Rojas

,

Patricia Barrio Fernandez