eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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4/2021
vol. 7
 
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abstract:
Original paper

Impact of COVID-19 infection on liver and alimentary tract: clinical insight

Taha Mohammad Hassanin
1
,
Hanaa Fathelbab
1
,
Hala Ibraheem
1
,
Sahar Hassany
2
,
Amr Zaghloul
3
,
Assmaa Fathelbab
4

  1. Endemic Medicine and Gastroenterology Department, Minia University Faculty of Medicine, Egypt
  2. Tropical Medicine and Gastroenterology Department, Assiut University Faculty of Medicine, Egypt
  3. Tropical Medicine and Gastroenterology Department, Sohag University Faculty of Medicine, Egypt
  4. Radiology Department, Minia University Faculty of Medicine, Egypt
Clin Exp HEPATOL 2021; 7, 4: 364-369
DOI: https://doi.org/10.5114/ceh.2021.110986
Online publish date: 2021/11/26
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Introduction
Our aim was to evaluate the impact of COVID-19 infection on the liver and alimentary tract.

Material and methods
This is a retrospective multicenter study that was performed in non-intensive care units (ICU) at Minia, Assiut, and Sohag University Hospitals from March 1st, 2020 to August 1st, 2020. The clinical characteristics of 1238 consecutively confirmed COVID-19 discharged cases were enrolled. Patients with respiratory distress were recorded as severe cases, while others were recorded as mild-moderate cases. Patients with ≥ 2× upper limit of normal of alanine aminotransferase (ALT), aspartate aminotransferase (AST), or bilirubin were defined as patients with liver injury, while others were recorded as patients without liver injury.

Results
The severe group included 460 patients (37.2%) while the mild-moderate group included 778 patients (62.8%). Fever, white blood cell (WBC) and C-reactive protein (CRP) levels were significantly higher in the severe group (p < 0.05). The hepatic injury group included 296 patients (23.9%) while the group without hepatic injury included 942 patients (76.1%). Males were more likely to have liver injury (p < 0.05). Fever and abdominal pain were significantly higher in the hepatic injury group. Patients with liver injury had increased levels of WBCs, CRP and chest computed tomography (CT) score and had a longer hospital stay (p < 0.05). Chest CT score was a predictor of liver injury (p < 0.05).

Conclusions
Liver injury in non-ICU hospitalized COVID-19 patients is common but it is mild and has a good prognosis. Liver injury may be related to the degree of chest CT lesions.

keywords:

hepatic injury, gastrointestinal symptoms, COVID-19, chest symptoms, chest CT lesions in COVID-19 patients
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