Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report

Oskar Sylwestrzak; Julia Murlewska; Łukasz Sokołowski; Monika Tadros-Zins; Michał Krekora; Iwona Maroszyńska; Maria Respondek-Liberska

doi:10.5114/pcard.2023.135555

eISSN: 2449-6731
ISSN: 2449-6723

Prenatal Cardiology

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abstract:

Case report

Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report

Oskar Sylwestrzak

¹

,

Julia Murlewska

¹

,

Łukasz Sokołowski

¹

,

Monika Tadros-Zins

²

,

Michał Krekora

²

,

Iwona Maroszyńska

³

,

Maria Respondek-Liberska

^{1, 4}

Department of Prenatal Cardiology, Polish Mother’s Memorial Hospital – Research Institute in Lodz, Poland
Department of Obstetrics and Gynaecology, Polish Mother’s Memorial Hospital – Research Institute in Lodz, Poland
Department of Neonatal Intensive Care and Congenital Malformation in Neonates and Infants, Polish Mother’s Memorial Hospital – Research Institute in Lodz, Poland
Department of Diagnoses and Prevention of Fetal Malformations, Medical University of Lodz, Poland

Prenat Cardio 2023; 13 (1): 43-46

DOI: https://doi.org/10.5114/pcard.2023.135555

Online publish date: 2024/02/19

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AMA

Sylwestrzak O, Murlewska J, Sokołowski Ł, et al. Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report. Prenatal Cardiology. 2023;(1):43-46. doi:10.5114/pcard.2023.135555.

APA

Sylwestrzak, O., Murlewska, J., Sokołowski, Ł., Tadros-Zins, M., Krekora, M.,  & Maroszyńska, I. et al. (2023). Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report. Prenatal Cardiology, (1), 43-46. https://doi.org/10.5114/pcard.2023.135555

Chicago

Sylwestrzak, Oskar, Julia Murlewska, Łukasz Sokołowski, Monika Tadros-Zins, Michał Krekora, Iwona Maroszyńska,  and Maria Respondek-Liberska. 2023. "Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report". Prenatal Cardiology  (1): 43-46. doi:10.5114/pcard.2023.135555.

Harvard

Sylwestrzak, O., Murlewska, J., Sokołowski, Ł., Tadros-Zins, M., Krekora, M., Maroszyńska, I.,  and Respondek-Liberska, M. (2023). Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report. Prenatal Cardiology, (1), pp.43-46. https://doi.org/10.5114/pcard.2023.135555

MLA

Sylwestrzak, Oskar et al. "Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report." Prenatal Cardiology, no. 1, 2023, pp. 43-46. doi:10.5114/pcard.2023.135555.

Vancouver

Sylwestrzak O, Murlewska J, Sokołowski Ł, Tadros-Zins M, Krekora M, Maroszyńska I et al. Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report. Prenatal Cardiology. 2023;(1):43-46. doi:10.5114/pcard.2023.135555.

PlumX metrics:

A case of the fetus exposed to elevated phenylalanine concentration, who presented structural and functional cardiovascular changes and pulmonary injury in uncontrolled phenylketonuria of the pregnant woman. Continued fetal echocardiographic monitoring in the third trimester of pregnancy allowed to present fetal functional cardiovascular abnormalities and suspect neonatal persistent pulmonary hypertension. To the best of our knowledge, prenatal detection of persistent pulmonary hypertension in the case of maternal phenylketonuria on the newborn has not been reported before, and increased phenylalanine might be an additional factor influencing pulmonary tissue development.

keywords:

Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report

Oskar Sylwestrzak 1 , Julia Murlewska 1 , Łukasz Sokołowski 1 , Monika Tadros-Zins 2 , Michał Krekora 2 , Iwona Maroszyńska 3 , Maria Respondek-Liberska 1, 4

case report, pulmonary hypertension, fetal echocardiography, fetal, phenylketonuria

Oskar Sylwestrzak

¹

,

Julia Murlewska

¹

,

Łukasz Sokołowski

¹

,

Monika Tadros-Zins

²

,

Michał Krekora

²

,

Iwona Maroszyńska

³

,

Maria Respondek-Liberska

^{1, 4}