Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia

Kanjaporn Sirisomboonlarp; Wanvisa Udomsinprasert; Ellie McConachie; Thamonwan Woraruthai; Yong Poovorawan; Sittisak Honsawek

doi:10.5114/ceh.2019.83156

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia

Kanjaporn Sirisomboonlarp

¹

,

Wanvisa Udomsinprasert

^{1, 2}

,

Ellie McConachie

¹

,

Thamonwan Woraruthai

¹

,

Yong Poovorawan

³

,

Sittisak Honsawek

¹

Department of Biochemistry, Osteoarthritis and Musculoskeleton Research Unit, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand

Clin Exp HEPATOL 2019; 5, 1: 48–54

DOI: https://doi.org/10.5114/ceh.2019.83156

Online publish date: 2019/03/01

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AMA

Sirisomboonlarp K, Udomsinprasert W, McConachie E, Woraruthai T, Poovorawan Y, Honsawek S. Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia. Clinical and Experimental Hepatology. 2019;5(1):48-54. doi:10.5114/ceh.2019.83156.

APA

Sirisomboonlarp, K., Udomsinprasert, W., McConachie, E., Woraruthai, T., Poovorawan, Y.,  & Honsawek, S. (2019). Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia. Clinical and Experimental Hepatology, 5(1), 48-54. https://doi.org/10.5114/ceh.2019.83156

Chicago

Sirisomboonlarp, Kanjaporn, Wanvisa Udomsinprasert, Ellie McConachie, Thamonwan Woraruthai, Yong Poovorawan,  and Sittisak Honsawek. 2019. "Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia". Clinical and Experimental Hepatology 5 (1): 48-54. doi:10.5114/ceh.2019.83156.

Harvard

Sirisomboonlarp, K., Udomsinprasert, W., McConachie, E., Woraruthai, T., Poovorawan, Y.,  and Honsawek, S. (2019). Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia. Clinical and Experimental Hepatology, 5(1), pp.48-54. https://doi.org/10.5114/ceh.2019.83156

MLA

Sirisomboonlarp, Kanjaporn et al. "Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia." Clinical and Experimental Hepatology, vol. 5, no. 1, 2019, pp. 48-54. doi:10.5114/ceh.2019.83156.

Vancouver

Sirisomboonlarp K, Udomsinprasert W, McConachie E, Woraruthai T, Poovorawan Y, Honsawek S. Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia. Clinical and Experimental Hepatology. 2019;5(1):48-54. doi:10.5114/ceh.2019.83156.

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Aim of the study
Biliary atresia (BA) is an uncommon disorder of the liver and bile ducts affecting infants and is characterized by progressive fibrosclerosing obstruction of the extrahepatic biliary tree leading to end-stage liver failure. The purpose of this study was to determine serum glypican-3 (GPC3) levels and liver stiffness in children with BA and the correlation of glypican-3 with clinical parameters.

Material and methods
Seventy-five post-Kasai BA patients and 28 healthy age-matched controls were registered. Serum GPC3 levels were examined by enzyme-linked immunosorbent assay. Liver stiffness measurement was analyzed by transient elastography.

Results
BA patients had significantly greater serum GPC3 and liver stiffness values than controls (p < 0.001). Serum GPC3 and liver stiffness values were significantly higher in jaundiced BA patients than in non-jaundiced BA patients (p < 0.001). Additionally, serum glypican-3 was associated with liver stiffness and serum total bilirubin (p < 0.001, respectively).

Conclusions
Elevated serum GPC3 levels were associated with hepatic dysfunction and the severity of BA. As a result, serum GPC3 and liver stiffness might serve as biomarkers reflecting the deterioration of hepatic function and the outcome in post-Kasai BA.

keywords:

Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia

Kanjaporn Sirisomboonlarp 1 , Wanvisa Udomsinprasert 1, 2 , Ellie McConachie 1 , Thamonwan Woraruthai 1 , Yong Poovorawan 3 , Sittisak Honsawek 1

biliary atresia, glypican-3, jaundice, liver stiffness, severity

Kanjaporn Sirisomboonlarp

¹

,

Wanvisa Udomsinprasert

^{1, 2}

,

Ellie McConachie

¹

,

Thamonwan Woraruthai

¹

,

Yong Poovorawan

³

,

Sittisak Honsawek

¹