Influence of surgical castration on serum levels of the lipid peroxidation end-products

Ewa Baszak; Ewa Szpringer-Boguń; Krzysztof Lutnicki; Leszek Janeczek; Radosław Rola; Tomasz Paszkowski

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

1/2002
vol. 1

Send email

Copy url:

abstract:

Influence of surgical castration on serum levels of the lipid peroxidation end-products

Ewa Baszak

,

Ewa Szpringer-Boguń

,

Krzysztof Lutnicki

,

Leszek Janeczek

,

Radosław Rola

,

Tomasz Paszkowski

(Prz Menopauz 2002; 1: 33–37)

Online publish date: 2004/03/03

View full text Get citation

Rationale for the study. The literature contains data suggesting that a postmenopausal woman is exposed to an oxidative stress due to the low estrogen levels. Very scanty data are however available considering the prooxidant-antioxidant homeostasis in the early postoperative period following surgical castration.
Objective. The purpose of this study was to characterize the intensity of lipid peroxidation in the perioperative period in premenopausal women who underwent total abdominal hysterectomy with bilateral salpingooophorectomy (TAH&BSO).
Patients. Fourty premenopausal women aged 44–55 years were included into this study. The indication for the TAH&BSO was menorrhagia due to uterine fibroids or benign endometrial hyperplasia.
Biological material and laboratory analyses. In all the examined patients venous blood was collected before the operation as well as in the postoperative day 2. In the serum samples, level of lipid peroxides was measured, using spectrophotometric TBARs (thiobarbituric acid reactive substatnces) method.
Results/Conclusions 1. In the postoperative day 2 levels od lipid peroxidation end-products increase significantly. 2. In the early postoperative period after surgical castration, patients are predisposed to the oxidative stress.

keywords:

Influence of surgical castration on serum levels of the lipid peroxidation end-products

Ewa Baszak , Ewa Szpringer-Boguń , Krzysztof Lutnicki , Leszek Janeczek , Radosław Rola , Tomasz Paszkowski

surgical castration, lipid peroxidation, oxidative stress

Ewa Baszak

,

Ewa Szpringer-Boguń

,

Krzysztof Lutnicki

,

Leszek Janeczek

,

Radosław Rola

,

Tomasz Paszkowski