Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases

Agnieszka Wasilewska; Marta Winiarska; Małgorzata Olszewska; Lidia Rudnicka

doi:10.5114/ada.2016.61599

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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4/2016
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abstract:

Review paper

Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases

Agnieszka Wasilewska

,

Marta Winiarska

,

Małgorzata Olszewska

,

Lidia Rudnicka

Adv Dermatol Allergol 2016; XXXIII (4): 247–252

DOI: https://doi.org/10.5114/ada.2016.61599

Online publish date: 2016/08/16

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Psoriasis is a chronic skin disease caused by the excessive secretion of inflammatory cytokines. Available therapeutic options include biologic drugs such as tumor necrosis factor alpha inhibitors and interleukin 12/23 (IL-12/23) inhibitors. The recent discovery of IL-17, which contributes to development of psoriasis, opened new possibilities for further treatment modalities. Currently, one anti-IL17 biological agent is approved for the treatment – a fully human monoclonal antibody that targets IL-17A (secukinumab). Further clinical trials, including a humanized IgG4 specific for IL-17 (ixekizumab) and a fully human antibody that targets the IL-17 receptor A (brodalumab).

keywords:

Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases

Agnieszka Wasilewska , Marta Winiarska , Małgorzata Olszewska , Lidia Rudnicka

alopecia areata, fynomer, lichen planus, pemphigoid, pemphigus

Agnieszka Wasilewska

,

Marta Winiarska

,

Małgorzata Olszewska

,

Lidia Rudnicka