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ISSN: 1233-9687
Polish Journal of Pathology
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2/2018
vol. 69
 
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abstract:

Intraoral manifestation of systemic AL amyloidosis with unique microscopic presentation of intracellular amyloid deposition in striated muscles

Zuzanna Oruba
,
Tomasz Kaczmarzyk
,
Katarzyna Urbańczyk
,
Artur Jurczyszyn
,
Szymon Fornagiel
,
Krystyna Gałązka
,
Anna Bednarczyk
,
Maria Chomyszyn-Gajewska

Pol J Pathol 2018; 69 (2): 200-204
DOI: https://doi.org/10.5114/pjp.2018.76705
Online publish date: 2018/07/06
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We report the history of a 59-year old patient with systemic AL amyloidosis of intraoral manifestation. The patient first presented with complaints about dysphagia and remarkable enlargement of the tongue with highly reduced mobility, as well as bilateral submucosal thickenings on the cheeks. Histopathological examination of the incisional biopsy of the buccal mucosa and underlying tissues revealed AL amyloidosis. The microscopic presentation was, however, unique, as the amyloid deposits were present intracellularly in the striated muscles. The subsequent bone marrow biopsy confirmed the diagnosis of primary amyloidosis/multiple myeloma – associated amyloidosis.
keywords:

AL amyloidosis, amyloid, multiple myeloma, macroglossia, oral manifestation
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