eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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2/2012
vol. 63
 
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abstract:

Invasive lobular carcinoma of the breast: cytometric and immunohistochemical characteristics of 96 cases

Piotr Skotnicki
,
Janusz Ryś
,
Paweł Blecharz
,
Marian Reinfuss
,
Jerzy Jakubowicz
,
Aleksandra Ambicka
,
Anna Kruczak
,
Bożena Lackowska

POL J PATHOL 2012; 2: 112-120
Online publish date: 2012/08/03
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The aim of the study was to present microscopic, cytometric and immunohistochemical characteristics of a group of 96 invasive lobular carcinomas (ILC) of the breast. Ninety six patients treated surgically at the Department of Surgical Oncology, Centre of Oncology – Maria Skłodowska-Curie Memorial Institute, Cracow Branch, between 1983 and 1996, were included into the study. In 56 (58.3%) cases, a classical pattern of ILC was diagnosed, whereas atypical variants (solid, pleomorphic, pleomorphic with signet ring cells, signet ring cell, and tubulolobular) were recognized in 40 (41.7%) cases. ILC was characterized by lack of E-cadherin expression, high rate of steroid receptor expression, low rate of P53 and c-erb-B2 expressing tumours, low MIB-1 labelling index, and low S phase fraction, as well as high rate of diploid lesions.
keywords:

invasive lobular carcinoma, flow cytometry, immunohistochemistry
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