Investigating the association of atopy and aeroallergen
sensitization and chronic spontaneous urticaria

Hossein Esmaeilzadeh; Mehrdad Eskandarisani; Hesamedin Nabavizadeh; Soheila Alyasin; Mouhebat Vali; Negar Mortazavi

doi:10.5114/ada.2022.113805

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Investigating the association of atopy and aeroallergen sensitization and chronic spontaneous urticaria

Hossein Esmaeilzadeh

^{1, 2}

,

Mehrdad Eskandarisani

³

,

Hesamedin Nabavizadeh

^{1, 2}

,

Soheila Alyasin

^{1, 2}

,

Mouhebat Vali

³

,

Negar Mortazavi

⁴

Allergy Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

Adv Dermatol Allergol 2022; XXXIX (1): 121-125

DOI: https://doi.org/10.5114/ada.2022.113805

Online publish date: 2022/02/28

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AMA

Esmaeilzadeh H, Eskandarisani M, Nabavizadeh H, Alyasin S, Vali M, Mortazavi N. Investigating the association of atopy and aeroallergen
sensitization and chronic spontaneous urticaria. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(1):121-125. doi:10.5114/ada.2022.113805.

APA

Esmaeilzadeh, H., Eskandarisani, M., Nabavizadeh, H., Alyasin, S., Vali, M.,  & Mortazavi, N. (2022). Investigating the association of atopy and aeroallergen
sensitization and chronic spontaneous urticaria. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(1), 121-125. https://doi.org/10.5114/ada.2022.113805

Chicago

Esmaeilzadeh, Hossein, Mehrdad Eskandarisani, Hesamedin Nabavizadeh, Soheila Alyasin, Mouhebat Vali,  and Negar Mortazavi. 2022. "Investigating the association of atopy and aeroallergen
sensitization and chronic spontaneous urticaria". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 39 (1): 121-125. doi:10.5114/ada.2022.113805.

Harvard

Esmaeilzadeh, H., Eskandarisani, M., Nabavizadeh, H., Alyasin, S., Vali, M.,  and Mortazavi, N. (2022). Investigating the association of atopy and aeroallergen
sensitization and chronic spontaneous urticaria. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(1), pp.121-125. https://doi.org/10.5114/ada.2022.113805

MLA

Esmaeilzadeh, Hossein et al. "Investigating the association of atopy and aeroallergen
sensitization and chronic spontaneous urticaria." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 39, no. 1, 2022, pp. 121-125. doi:10.5114/ada.2022.113805.

Vancouver

Esmaeilzadeh H, Eskandarisani M, Nabavizadeh H, Alyasin S, Vali M, Mortazavi N. Investigating the association of atopy and aeroallergen
sensitization and chronic spontaneous urticaria. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(1):121-125. doi:10.5114/ada.2022.113805.

Introduction
Chronic spontaneous urticaria (CSU) is a common skin allergic reaction with an unknown mechanism. There is inadequate evidence to support the role of aeroallergen sensitization in CSU.

Aim
The present study was conducted to investigate the association between the aeroallergen sensitivity and CSU.

Material and methods
In this cross-sectional study, 91 patients with CSU were recruited. Information on demographic characteristics was collected. The skin prick test (SPT) for most prevalent aeroallergens and pulmonary function test (PFT) were performed and the results were clinically matched to investigate the allergic rhinitis (AR) and asthma. Total serum immunoglobulin E (IgE) concentration was analysed in the subjects for the presence of atopy.

Results
Ninety one patients (75 of them were females) were enrolled in the study (with a mean age of 36.90 ±12.93 years). SPT result was positive in 75 (82.4%) subjects. Weeds (67 cases, 73.6%), trees (61 cases, 67%), and dust mites (55 cases, 60.4%) were the most common pollens in the positive SPT samples. Thirty-seven (40.7%) of the patients had allergic rhinitis. There was a statistically significant association between the presence of AR and positive SPT result (p = 0.002). Eight patients had allergic asthma and 45 (49.4%) of the patients had a total serum IgE level of more than 100 IU/ml.

Conclusions
Our results indicated a clear association between the presence of aeroallergen sensitivity and development of CSU. AR exists as a co-morbidity of CSU.

keywords:

Investigating the association of atopy and aeroallergen sensitization and chronic spontaneous urticaria

Hossein Esmaeilzadeh 1, 2 , Mehrdad Eskandarisani 3 , Hesamedin Nabavizadeh 1, 2 , Soheila Alyasin 1, 2 , Mouhebat Vali 3 , Negar Mortazavi 4

rticaria, atopy, aeroallergens, allergy, skin prick test

Hossein Esmaeilzadeh

^{1, 2}

,

Mehrdad Eskandarisani

³

,

Hesamedin Nabavizadeh

^{1, 2}

,

Soheila Alyasin

^{1, 2}

,

Mouhebat Vali

³

,

Negar Mortazavi

⁴