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Journal of Stomatology
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2/2023
vol. 76
 
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abstract:
Original paper

Investigation of cyto-toxicity of an innovative BIOfactor MTA product in different human cells: a pilot study

Gülter Devrim Akyol
1
,
Mukadder Inci Baser Kolcu
2
,
Nazlı Zeynep Alpaslan
3
,
Filiz Taşpınar
4
,
Rodi Yusuf Mızrak
5
,
Serap Keskin Tunç
5
,
Bülend İnanç
6

  1. Endodontics, Dentiora Dental Clinic, Turkey
  2. Department of Medical Education and Informatics, Süleyman Demirel University, Faculty of Medicine, Turkey
  3. Department of Periodontology, Van Yüzüncü Yıl University, Faculty of Dentistry, Turkey
  4. Department of Physiology, Aksaray University, Faculty of Medicine, Turkey
  5. Department of Oral and Maxillofacial Surgery, Hamidiye Faculty of Dentistry, University of Health Sciences, Turkey
  6. Department of Periodontology, Trakya University, Faculty of Dentistry, Turkey
J Stoma 2023; 76, 2: 71-76
DOI: https://doi.org/10.5114/jos.2023.128770
Online publish date: 2023/06/26
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Introduction
Mineral trioxide aggregate (MTA) is one of the most popular and convenient material among current endodontic materials. In addition to MTA advantages, there are also features that need to be improved. Color stability and consistency are notorious concerns in MTA, and materials need improvement regarding theses aspects. There are companies, which work on these contents.

Objectives
The aim of this study was to investigate the cyto-toxicity of Biodentine, Angelus MTA, BIOfactor MTA on 3T3L-1 fibroblast, and Saos-2 osteosarcoma cell lines with different dilution of all products.

Material and methods
3T3-1 fibroblast was applied to stimulate pulp cells in cell viability test. In order to gene­rate an osteoblastic cell-like model, only Saos-2 cells were used. MTT test was utilized to measure cell cyto-toxicity in different dilution of all MTA products. SPSS package program was applied to perform Kruskal-Wallis, one-way ANOVA and two-way ANOVA tests.

Results
According to results, while Biodentine, Angelus MTA and BIOfactor MTA showed cyto-toxic effects in 1 : 1 and 1 : 2 dilutions, they were not cyto-toxic in 1 : 4 and 1 : 8 dilutions.

Conclusions
MTA products have similar cyto-toxicity. BIOfactor MTA has a cyto-toxic effect as other similar products.

keywords:

MTT assay, Biodentine, cyto-toxicity, BIOfactor MTA, Angelus MTA

  
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