eISSN: 2081-2833
ISSN: 2081-0016
Medycyna Paliatywna/Palliative Medicine
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
2/2023
vol. 15
 
Share:
Share:
abstract:
Guidelines/recommendations

Is there a place for cannabigerol in symptomatic treatment?

Michał Graczyk
1
,
Łukasz Pawlak
2
,
Agata Anna Lewandowska
3

  1. Katedra Opieki Paliatywnej, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, Bydgoszcz, Polska
  2. Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, Bydgoszcz, Polska
  3. 10. Wojskowy Szpital Kliniczny z Polikliniką SPZOZ, Bydgoszcz. Polska
Medycyna Paliatywna 2023; 15(2): 50–58
Online publish date: 2023/09/20
View full text Get citation
 
PlumX metrics:
Cannabigerol (CBG) is one of the compounds derived from Cannabis sativa L. that has drawn researchers’ attention in recent years. In the process of biosynthesis, CBG acts as a precursor to various phytocannabinoids, including cannabidiol (CBD) and Δ9-tetrahydrocannabinol. After administration into the human body, however, it does not result in the formation of other cannabinoids due to the lack of necessary conversion pathways. Cannabigerol acts on serotonergic, α2 adrenergic receptors, peroxisome proliferator-activated receptors, and the cannabinoid receptor family. In addition, it presents an inhibitory effect on several anti-inflammatory mediators. Despite its weak interaction with CB1 and CB2 cannabinoid receptors, among phytocannabinoids it is the most potent ligand of the transient receptor vanilloid potential 1. When the endocannabinoid system becomes disrupted in various disease states, CBG, through its potential effects, can have an impact on maintaining homeostasis in the body. The range of its biological activity includes anti-inflammatory, antibacterial, antifungal, and neuromodulatory properties, as well as the regulation of redox balance. Applications for CBG have already been found in astrointestinal, metabolic, and neurological disorders, as well as numerous inflammatory diseases. We are currently witnessing a widespread increase in the use of CBG in medicine due to its beneficial effects on health while lacking psychoactivity. Despite the growing interest, caution should be exercised in the use of CBG and CBD due to possible interactions with other medications.
keywords:

cannabinoids, anti-inflammatory effects, cannabigerol, Cannabis sativa, CBG

FEATURED PRODUCTS
BOOKS
Medycyna Paliatywna
Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.