Is there any significance of lung cancer histology to compared the diagnostic accuracies of <sup>18</sup>F-FDG-PET/CT and <sup>99m</sup>Tc-MDP BS for the detection of bone metastases in advanced NSCLC?

Ali Inal; Muhammed Ali Kaplan; Mehmet Kucukoner; Zuhat UrakcI; Zeki Dostbi; Hail Komek; Hakan Onder; Bekir Tasdemir; Abdurrahman Isikdogan

doi:10.5114/wo.2014.42725

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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2/2014
vol. 18

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abstract:

Original paper

Is there any significance of lung cancer histology to compared the diagnostic accuracies of ¹⁸F-FDG-PET/CT and ^99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?

Ali Inal

,

Muhammed Ali Kaplan

,

Mehmet Kucukoner

,

Zuhat UrakcI

,

Zeki Dostbi

,

Hail Komek

,

Hakan Onder

,

Bekir Tasdemir

,

Abdurrahman Isikdogan

Contemp Oncol (Pozn) 2014; 18 (2): 106–110

DOI: https://doi.org/10.5114/wo.2014.42725

Online publish date: 2014/06/03

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AMA

Inal A, Kaplan M, Kucukoner M, et al. Is there any significance of lung cancer histology to compared the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?. Contemporary Oncology/Współczesna Onkologia. 2014;18(2):106-110. doi:10.5114/wo.2014.42725.

APA

Inal, A., Kaplan, M., Kucukoner, M., UrakcI, Z., Dostbi, Z.,  & Komek, H. et al. (2014). Is there any significance of lung cancer histology to compared the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?. Contemporary Oncology/Współczesna Onkologia, 18(2), 106-110. https://doi.org/10.5114/wo.2014.42725

Chicago

Inal, Ali, Muhammed Ali Kaplan, Mehmet Kucukoner, Zuhat UrakcI, Zeki Dostbi, Hail Komek,  and Hakan Onder et al. 2014. "Is there any significance of lung cancer histology to compared the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?". Contemporary Oncology/Współczesna Onkologia 18 (2): 106-110. doi:10.5114/wo.2014.42725.

Harvard

Inal, A., Kaplan, M., Kucukoner, M., UrakcI, Z., Dostbi, Z., Komek, H., Onder, H., Tasdemir, B.,  and Isikdogan, A. (2014). Is there any significance of lung cancer histology to compared the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?. Contemporary Oncology/Współczesna Onkologia, 18(2), pp.106-110. https://doi.org/10.5114/wo.2014.42725

MLA

Inal, Ali et al. "Is there any significance of lung cancer histology to compared the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?." Contemporary Oncology/Współczesna Onkologia, vol. 18, no. 2, 2014, pp. 106-110. doi:10.5114/wo.2014.42725.

Vancouver

Inal A, Kaplan M, Kucukoner M, UrakcI Z, Dostbi Z, Komek H et al. Is there any significance of lung cancer histology to compared the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?. Contemporary Oncology/Współczesna Onkologia. 2014;18(2):106-110. doi:10.5114/wo.2014.42725.

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Aim of the study: Bone scintigraphy (BS) and fluorine-18 deoxyglucose positron emission tomography computed tomography (¹⁸F-FDG-PET/CT) are widely used for the detection of bone involvement. The optimal imaging modality for the detection of bone metastases in histological subgroups of non-small cell lung cancer (NSCLC) remains ambiguous. The aim of this study was to compare the efficacy of ¹⁸F-FDG-PET/C and ^99mTc-methylene diphosphonate (^99mTc-MDP) BS in the detection of bone metastases of patients in NSCLC. Specifically, we compared the diagnostic accuracies of these imaging techniques evaluating bone metastasis in histological subgroups of NSCLC.

Material and methods: Fifty-three patients with advanced NSCLC, who had undergone both ¹⁸F-FDG-PET/CT and BS and were eventually diagnosed as having bone metastasis, were enrolled in this retrospective study.

Results: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of ¹⁸F-FDG-PET/CT and BS were 90.4%, 99.4%, 98.1%, 96.6%, 97.0% and 84.6%, 93.1%, 82.5%, 93.2, 90.8%, respectively. The κ statistics were calculated for ¹⁸F-FDG-PET/CT and BS. The κ-value was 0.67 between ¹⁸F-FDG-PET/CT and BS in all patients. On the other hand, the κ-value was 0.65 in adenocarcinoma, and 0.61 in squamous cell carcinoma between ¹⁸F-FDG-PET/CT and BS.

The κ-values suggested excellent agre-ement between all patients and histological subgroups of NSCLC.

Conclusions: ¹⁸F-FDG-PET/CT was morefavorable than BS in the screening of metastatic bone lesions, but the trend did not reach statistical significance in all patients and histological subgroups of NSCLC. Our results need to be validated in prospective and larger study clinical trials to further clarify this topic.

keywords:

Is there any significance of lung cancer histology to compared the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?

Ali Inal , Muhammed Ali Kaplan , Mehmet Kucukoner , Zuhat UrakcI , Zeki Dostbi , Hail Komek , Hakan Onder , Bekir Tasdemir , Abdurrahman Isikdogan

18F-FDG-PET/CT, 99mTc- methylene diphosphonate bone scintigraphy, bone metastases, non-small cell lung cancer

Is there any significance of lung cancer histology to compared the diagnostic accuracies of ¹⁸F-FDG-PET/CT and ^99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?

Ali Inal

,

Muhammed Ali Kaplan

,

Mehmet Kucukoner

,

Zuhat UrakcI

,

Zeki Dostbi

,

Hail Komek

,

Hakan Onder

,

Bekir Tasdemir

,

Abdurrahman Isikdogan

¹⁸F-FDG-PET/CT, ^99mTc- methylene diphosphonate bone scintigraphy, bone metastases, non-small cell lung cancer