Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study

Salvatore Giovanni Vitale; Salvatore Caruso; Agnese Maria Chiara Rapisarda; Stefano Cianci; Antonio Cianci

doi:10.5114/pm.2018.73791

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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Original paper

Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study

Salvatore Giovanni Vitale

,

Salvatore Caruso

,

Agnese Maria Chiara Rapisarda

,

Stefano Cianci

,

Antonio Cianci

Menopause Rev 2018; 17(1): 32-38

DOI: https://doi.org/10.5114/pm.2018.73791

Online publish date: 2018/03/02

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AMA

Vitale S, Caruso S, Rapisarda A, Cianci S, Cianci A. Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study. Menopause Review/Przegląd Menopauzalny. 2018;17(1):32-38. doi:10.5114/pm.2018.73791.

APA

Vitale, S., Caruso, S., Rapisarda, A., Cianci, S.,  & Cianci, A. (2018). Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study. Menopause Review/Przegląd Menopauzalny, 17(1), 32-38. https://doi.org/10.5114/pm.2018.73791

Chicago

Vitale, Salvatore Giovanni, Salvatore Caruso, Agnese Maria Chiara Rapisarda, Stefano Cianci,  and Antonio Cianci. 2018. "Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study". Menopause Review/Przegląd Menopauzalny 17 (1): 32-38. doi:10.5114/pm.2018.73791.

Harvard

Vitale, S., Caruso, S., Rapisarda, A., Cianci, S.,  and Cianci, A. (2018). Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study. Menopause Review/Przegląd Menopauzalny, 17(1), pp.32-38. https://doi.org/10.5114/pm.2018.73791

MLA

Vitale, Salvatore Giovanni et al. "Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study." Menopause Review/Przegląd Menopauzalny, vol. 17, no. 1, 2018, pp. 32-38. doi:10.5114/pm.2018.73791.

Vancouver

Vitale S, Caruso S, Rapisarda A, Cianci S, Cianci A. Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study. Menopause Review/Przegląd Menopauzalny. 2018;17(1):32-38. doi:10.5114/pm.2018.73791.

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Introduction
Menopause results in metabolic changes that contribute to increase risk of cardiovascular diseases: increase in low density lipoprotein (LDL) and triglycerides and decrease in high density lipoprotein (HDL), weight gain are associated with a correspondent increase in incidence of hypertension and diabetes.The aim of this study was to evaluate the effect of a preparation of isoflavones, calcium vitamin D and inulin in menopausal women.

Material and methods
We performed a prospective, randomized, placebo< /i>-controlled, parallel-group study. A total of 50 patients were randomized to receive either oral preparations of isoflavones (40 mg), calcium (500 mg) vitamin D (300 UI) and inulin (3 g) or placebo (control group). Pre- and post-treatment assessment of quality of life and sexual function were performed through Menopause-Specific Quality of Life Questionnaire (MENQOL) and Female Sexual Function Index (FSFI); evaluations of anthropometric indicators, body composition through bioelectrical impedance analyser, lumbar spine and proximal femur T-score and lipid profile were performed.

Results
After 12 months, a significant reduction in MENQOL vasomotor, physical and sexual domain scores (p < 0.05) and a significant increase in all FSFI domain scores (p < 0.05) were observed in treatment group. Laboratory tests showed significant increase in serum levels of HDL (p < 0.05). No significant changes of lumbar spine and femur neck T-score (p > 0.05) were found in the same group.

Conclusions
According to our data analysis, isoflavones, calcium, vitamin D and inulin may exert favourable effects on menopausal symptoms and signs.

keywords:

Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study

Salvatore Giovanni Vitale , Salvatore Caruso , Agnese Maria Chiara Rapisarda , Stefano Cianci , Antonio Cianci

menopause, isoflavones, vitamin D, inulin, lipid metabolism

Salvatore Giovanni Vitale

,

Salvatore Caruso

,

Agnese Maria Chiara Rapisarda

,

Stefano Cianci

,

Antonio Cianci