Itopride in the treatment of kinetic disorders of gastrointestinal tract

Jan Chojnacki

doi:10.5114/pg.2011.23139

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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3/2011
vol. 6

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abstract:

Review paper

Itopride in the treatment of kinetic disorders of gastrointestinal tract

Jan Chojnacki

Przegląd Gastroenterologiczny 2011; 6 (3): 139–145

DOI: https://doi.org/10.5114/pg.2011.23139

Online publish date: 2011/07/04

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Itopride hydrochloride is a novel prokinetic which improves gastrointestinal motility by a dual mechanism of action. Firstly, it enhances the release of acetylcholine in the myenteric plexus by antagonizing the action of dopamine on the D2 receptors on the post-synaptic cholinergic nerves. Secondly, it prevents hydrolysisof the acetylcholine by acetylcholinesterase in the smooth mussels of the gastrointestinal tract. The results of many studies show that itopride, by virtue of its efficacy and tolerability may be considered us a drug of choice for the theatment of GERD, functional dyspepsia, gastroparesis and another functional disorders of gastrointestinal tract.

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Itopride in the treatment of kinetic disorders of gastrointestinal tract

Jan Chojnacki

dopamine, receptor D2, acetylcholine, itopride, prokinetic action